Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SS18 Polyclonal antibody

Uniprot No.

Q15532

Target Names

SS18

Alternative Names

MGC116875 antibody; Protein SSXT antibody; Protein SYT antibody; SS18 antibody; SSXT antibody; SSXT/SSX4v fusion antibody; SSXT_HUMAN antibody; Synovial sarcoma translocated to X chromosome antibody; Synovial sarcoma translocated to X chromosome protein antibody; Synovial sarcoma translocation chromosome 18 antibody; SYT antibody; SYT SSX1 antibody; SYT SSX2 antibody; SYT/SSX4v fusion protein antibody; SYTSSX1 antibody; SYTSSX2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Peptide sequence around aa.14~18(G-E-I-T-P) derived from Human SYT.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:1000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.

Gene References into Functions

Thirty-four patients (20 males and 14 females, mean of 31years) with SS18-SSX fusion-positive SS-HN were identified. The parapharyngeal region of the neck was the most common site PMID: 28249647
Kidney transplant recipients' polymorphisms of genes associated with telomere length, BICD1 and chromosome 18, but not hTERT, affect kidney allograft early and long-term function after transplantation. PMID: 27496426
Case Report: bronchial biphasic synovial sarcoma with SS18 gene rearrangement. PMID: 24429587
SYT gene split is associated with Synovial sarcoma. PMID: 24922679
SS18-SSX fusion type is a significant prognostic factor for patients with synovial sarcoma. PMID: 24022186
Studies show that in the 2 synovial sarcoma cell lines used, the fusion of SS18 with SSX leads to assembly of aberrant BAF complexes that become targeted to the Sox2 locus, with loss of repressive H3K27me3 marks, driving Sox2 expression and proliferation of these cells. PMID: 23540691
SYT-SSX2 was recruited to distinct loci across all chromosomes, and an overwhelming number of Polycomb-modified sites enriched with the trimethylated histone H3 on lysine 27 (H3K27me3) formed the main recruiting module for SYT-SSX2. PMID: 22594313
SS18-SSX1 and SS18-SSX2 variant translocations are associated with synovial sarcoma. PMID: 22976541
the initial events that likely occur when SYT-SSX2 is first expressed, and its dominant function in subverting the nuclear program of the stem cell, leading to its aberrant differentiation, as a first step toward transformation. PMID: 21996728
SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes PMID: 22442726
the fusion gene SYT-SSX should be considered to play important role on Synovial sarcoma cell growth via ERK pathway PMID: 21234732
Rearranged SYT wasdetected in all synovial sarcomas but not in any Ewing sarcoma/primitive neuroectodermal tumors PMID: 20660338
The SYT protein has a unique QPGY domain, which is also present in the largest subunits, p250 and the newly identified homolog p250R, of the corresponding SNF/SWI complexes PMID: 11734557
coexistence of fusions with SSX1 and SSX2 in synovial sarcomas PMID: 12037676
SYT may function as a general coactivator PMID: 15919756
demonstrate differentially expressed genes for the 2 major gene fusion variants in SS, SS18/X breakpoint 1 sarcoma (SSX1) and SS18/SSX2, and thereby suggest that these result in different downstream effects PMID: 16152617
SYT interacts with SYT-interacting protein/co-activator activator PMID: 16227627
SYT-SSX2 contributes to tumor development, in part through beta-catenin signaling. PMID: 16462762
SS18 and SS18L1 genes map within co-linear DNA segments that may have evolved through a relatively recent genomic duplication event. PMID: 16484776
The SS18-SSX2 fusion protein may act as a so-called transcriptional "activator-repressor," which induces downstream target gene deregulation through epigenetic mechanisms. PMID: 17018603
SYT-SSX1 fusion protein directly down-regulated the expression of COM1, a regulator of cell proliferation. PMID: 17101797
endogenous LHX4 binds to the CGA promoter and that LHX4-mediated CGA activation is enhanced by the SS18-SSX protein PMID: 17667940
this sarcoma showed a longer-than-expected PCR product. Direct sequencing of the product disclosed a novel SYT/SSX1 fusion transcript. PMID: 17721327
SS18-SSX1 can negatively regulate p53 tumor-suppressive function by increasing the stability of its negative regulator HDM2. PMID: 18234968
Findings showing a complex cryptic rearrangement that gives rise to the characteristic SYT-SSX2 fusion gene in a monophasic synovial sarcoma patient. PMID: 18992642
SYT-SSX fusion type was not correlated with survival synovial sarcoma. PMID: 18997619
provides evidence that, in the appropriate context, expression of the SYT-SSX2 oncogene leads to loss of polycomb function PMID: 19337376
SYT-SSX1 is an adverse predictor for disease-specific survival and metastasis-free survival, but has no relation to local recurrence-free survival in synovial sarcoma. PMID: 19385976
findings indicate that cytoplasmic SYT isoforms interact with actin filaments and function in the ability cells to bind and react to specific extracellular matrices PMID: 19649286

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Involvement in disease

A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

Subcellular Location

Nucleus.

Protein Families

SS18 family

Tissue Specificity

Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.

Database Links

HGNC: 11340

OMIM: 600192

KEGG: hsa:6760

STRING: 9606.ENSP00000414516

UniGene: Hs.129261

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Code	CSB-PA173100
Size	US$297
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Image	Western blot analysis of extracts from A431 cells using SYT Antibody.
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SS18 Antibody

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