STX12 Antibody

Code CSB-PA022890GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
STX12
Alternative Names
MGC51957 antibody; Stx12 antibody; STX12_HUMAN antibody; STX13 antibody; STX14 antibody; Syntaxin-12 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human STX12
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.
Gene References into Functions
  1. Data indicate that knockdown of syntaxin 13 (syx13) further increased the cellular toxicity caused by mutant CHMP2B (CHMP2BIntron5) expression. PMID: 24095276
  2. STX13 acts as a fusion SNARE in melanosomal trafficking pathways. PMID: 26208634
  3. The association of Src, EGFR and beta1 integrin is dependent upon membrane traffic that is mediated by syntaxin13 (officially known as STX12) and SNAP23. PMID: 24496451
  4. the importance of syntaxin-13 in the trafficking of matrix metalloproteinases during degradation of extracellular matrix substrates and subsequent cellular invasion PMID: 19910495
  5. ABCA1 forms a complex with syntaxin 13 and flotillin-1, residing at the plasma membrane and in phagosomes that are partially located in raft microdomains PMID: 15469992

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Subcellular Location
Endosome membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Endomembrane system; Single-pass type IV membrane protein; Cytoplasmic side. Early endosome membrane; Single-pass type IV membrane protein. Recycling endosome membrane; Single-pass type IV membrane protein.
Protein Families
Syntaxin family
Database Links

HGNC: 11430

OMIM: 606892

KEGG: hsa:23673

STRING: 9606.ENSP00000363054

UniGene: Hs.523855

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