Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
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Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.
Gene References into Functions
SUMF2 interacted with IL-13 and inhibited IL-13 secretion in bronchial smooth muscle cells and lymphocytes, which was independent of IL-13 glycosylation PMID: 19739097
structural analysis of human pFGE by X-ray crystallography [pFGE] PMID: 15687489
pFGE (SUMF2) is the paralog of the Calpha-formylglycine-generating enzyme PMID: 15708861
SUMF2 interacts with sulphatase-modifying factor 1 to regulate sulphatase activities. PMID: 15962010
pFGE is retained in the ER through its C-terminal tetrapeptide PGEL, a noncanonical variant of the classic KDEL ER-retention signal. PMID: 18266766
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Subcellular Location
Endoplasmic reticulum lumen.
Protein Families
Sulfatase-modifying factor family
Tissue Specificity
Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in kidney, liver and placenta.