SUPV3L1 Antibody

Datasheet

Code	CSB-PA814232LA01HU
Size	US$166
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Image	IHC image of CSB-PA814232LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Western Blot Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate All lanes: SUPV3L1 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 88 kDa Observed band size: 88 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SUPV3L1 Polyclonal antibody

Uniprot No.

Q8IYB8

Target Names

SUPV3L1

Alternative Names

6330443E10Rik antibody; ATP dependent RNA helicase SUPV3L1; mitochondrial antibody; ATP-dependent RNA helicase SUPV3L1 antibody; EC 3.6.1. antibody; MGC109049 antibody; mitochondrial antibody; OTTHUMP00000019719 antibody; S. Cerevisiae suppressor of var 1 3 like 1 antibody; suppressor of var1 (S.cerevisiae) 3 like 1 antibody; Suppressor of var1 3 like 1 (S. cerevisiae) antibody; Suppressor of var1 3 like 1 (S. cerevisiae)(SUV3) antibody; Suppressor of var1 3 like 1 antibody; Suppressor of var1 3 like protein 1 antibody; Suppressor of var1 3-like protein 1 antibody; SUPV 3 L 1 antibody; SUPV3L1 antibody; SUV 3 antibody; SUV 3 L 1 antibody; SUV3 antibody; SUV3 like protein 1 antibody; SUV3-like protein 1 antibody; SUV3_HUMAN antibody; SUV3L1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human ATP-dependent RNA helicase SUPV3L1, mitochondrial protein (499-786AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SUPV3L1 Antibody (Product code: CSB-PA814232LA01HU) is Non-conjugated. For SUPV3L1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA814232LB01HU	SUPV3L1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA814232LC01HU	SUPV3L1 Antibody, FITC conjugated
Biotin	CSB-PA814232LD01HU	SUPV3L1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:200-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.

Gene References into Functions

the nucleolar- associated human SUV3 protein is an important factor in regulation of the cell cycle. PMID: 28291845
the capacity of hSuv3 DNA unwinding activity might be sensitive to the local availability of specific inorganic cofactors PMID: 25446650
SUV3 bridges PNPase and mtPAP to form a transient complex in modulating mt-mRNA poly(A) tail length depending on the mitochondrial matrix Pi level. PMID: 24770417
Interaction between PNPase and hSuv3 is essential for efficient mitochondrial RNA degradation. PMID: 23221631
The hSuv3p activity was found to be necessary in the regulation of stability of mature, properly formed mRNAs and for removal of the noncoding processing intermediates transcribed from both H and L-strands. PMID: 19864255
Localisation of hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA. PMID: 12466530
Human SUV3 is an ATP-dependent multiple-substrate helicase; in addition to dsRNA and dsDNA unwinding activity, SUV3-70 and SUV3-83 can unwind heteroduplexes of RNA and DNA. PMID: 15096047
data suggest that hSUV3 is a housekeeping gene with an enhancer region & regulatory elements in basal promoter PMID: 15919122
Suv3 protein interacts with HBXIP, previously identified as a cofactor of survivin in suppression of apoptosis PMID: 16176273
Down-regulation of hSUV3 results in cell cycle perturbations and in apoptosis, which is both AIF- and caspase-dependent, and proceeds with the induction of p53. PMID: 17352692
Human SUV3 protein interacts with human WRN and BLM helicases. Silencing of the SUV3 gene in the human cell line HeLa resulted in elevation of homologous recombination as measured by the frequency of sister chromatid exchange during mitotic cell division. PMID: 17961633
SUV3 is essential for maintaining proper mitochondrial function, likely through a conserved role in mitochondrial RNA regulation. PMID: 18678873
The complex of hSUV3-hPNPase is an integral entity for efficient degradation of structured RNA and may be the long sought RNA-degrading complex in the mammalian mitochondria. PMID: 19509288

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Subcellular Location

Nucleus. Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.

Protein Families

Helicase family

Tissue Specificity

Broadly expressed.

Database Links

HGNC: 11471

OMIM: 605122

KEGG: hsa:6832

STRING: 9606.ENSP00000352678

UniGene: Hs.106469

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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