SV2C Antibody

1. These data establish SV2C as a mediator of dopamine neuron function and suggest that SV2C disruption is a unique feature of PD that likely contributes to dopaminergic dysfunction. PMID: 28246328
2. N-linked glycosylation of SV2C is required for binding and uptake of botulinum neurotoxin A. PMID: 27294781
3. Studies indicate that botulinum neurotoxins (BoNTs) in complex with its protein receptor, synaptic vesicle glycoprotein 2 (SV2) family member C represented a major advance for the detailed molecular understanding of BoNT-host cell receptor interactions. PMID: 25282537
4. A genetic variant in SV2C predicted clinically relevant bevacizumab-induced hypertension in two independent, randomised phase III trials. PMID: 25117820
5. In classical mesial temporal sclerosis 1A, the expression of SV2 isoforms is altered with a selective increase of SV2C in sprouting mossy fibres. PMID: 23617838
6. The fact that multiple SNPs in SV2C may impact response to atypical antipsychotics suggests that further evaluation of SNPs in this gene PMID: 23886675
7. high-resolution crystal structure of the BoNT/A receptor-binding domain in complex with the SV2C luminal domain PMID: 24240280

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HGNC: 30670

OMIM: 610291

KEGG: hsa:22987

STRING: 9606.ENSP00000423541

UniGene: Hs.646953