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TACC1 Antibody

Datasheet
Code CSB-PA023065GA01HU
Size $600
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Product Details

Uniprot No.
O75410
Target Names
TACC1
Alternative Names
DKFZp686K18126 antibody; Ga 55 antibody; Ga55 antibody; Gastric cancer antigen Ga 55 antibody; Gastric cancer antigen Ga55 antibody; KIAA1103 antibody; TACC 1 antibody; Tacc1 antibody; TACC1_HUMAN antibody; Taxin 1 antibody; Taxin-1 antibody; Taxin1 antibody; Transforming acidic coiled coil containing protein 1 antibody; Transforming acidic coiled-coil-containing protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human TACC1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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TACC1 Antibodies

TACC1 Proteins

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Target Background

Function
Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors. Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
Gene References into Functions
  1. The correlation between TACC1 expression and HER-2-positive status indicates synergistic regulation of these two prognostic markers in gastric carcinoma patients. PMID: 25297519
  2. TFF3 and TACC1 over-expression in epithelial cells of surgically resected gastric cancer tissues was an independent predictor of short survival in gastric cancer patients. PMID: 24358147
  3. These findings provide proof and the foundation for the molecular and biological relationships of ErbB-2 and TACC1 in breast cancer. PMID: 23354013
  4. study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity PMID: 22837387
  5. TACC1 depletion in the cell led to decreased RARalpha and TRalpha ligand-dependent transcriptional activity and to delocalization of TR from the nucleus to the cytoplasm. PMID: 20078863
  6. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells PMID: 11903063
  7. Down regulation of tacc1 controls mrna homeostasis in polarized cells and participates in oncogenic processes in human cancers PMID: 12165861
  8. REVIEW: genetics, expression, gene expression regulation, and function studies PMID: 12389629
  9. Splicing pattern of its mRNA is altered in stomach cancer PMID: 12547166
  10. TACC1 and the mitotic kinase Aurora B belong to the same complex during cytokinesis. PMID: 15064709
  11. Splice variants can be localized to different subcellular compartments in a cell-and tissue-specific manner. PMID: 16496324
  12. TACC1 and a three-gene expression signature (TACC1, NOV, and PTTG1) were identified as independent prognostic markers. PMID: 18984771

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Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody.; [Isoform 5]: Membrane; Lipid-anchor.; [Isoform 10]: Cytoplasm.
Protein Families
TACC family
Tissue Specificity
Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gast
Database Links

HGNC: 11522

OMIM: 605301

KEGG: hsa:6867

STRING: 9606.ENSP00000321703

UniGene: Hs.279245

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