TAF5L Antibody

Code CSB-PA004226
Size US$100
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  • Western Blot analysis of COS7 cells using TAF5L Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
TAF5L
Alternative Names
1110005N04Rik antibody; AI849020 antibody; OTTHUMP00000037470 antibody; OTTHUMP00000037471 antibody; PAF65 beta antibody; PAF65-beta antibody; PAF65B antibody; PCAF associated factor 65 beta antibody; PCAF-associated factor 65 beta antibody; TAF 5L antibody; TAF5 like RNA polymerase II p300/CBP associated factor (PCAF) associated factor 65 kD antibody; TAF5 like RNA polymerase II p300/CBP associated factor (PCAF) associated factor 65 kDa antibody; TAF5 like RNA polymerase II p300/CBP associated factor (PCAF) associated factor antibody; TAF5 like RNA polymerase II p300/CBP associated factor associated factor 65 kDa subunit 5L antibody; TAF5 like RNA polymerase II p300/CBP associated factor associated factor 65kDa antibody; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L antibody; Taf5l antibody; Taf5l protein antibody; TAF5L_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Monkey
Immunogen
Synthesized peptide derived from the Internal region of Human TAF5L.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state.
Gene References into Functions
  1. p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1 PMID: 16126174
  2. The TAF5L gene on chromosome 1q42 is associated tie type 1 diabetes in Russian patients. PMID: 16206511
  3. p300 or PCAF maintains myoblast viability as effectively as added growth factors through mechanisms requiring the acetyltransferase activity of PCAF but not of p300. PMID: 16672693
  4. latent cytoplasmic coactivator TORC2 mediates target gene activation in response to cAMP signaling by associating with CBP/p300 and increasing its recruitment to a subset of CREB target genes PMID: 17476304
  5. PCAF is a histone acetyltransferase which regulates gene transcription. PCAF interacts physically and functionally with PTEN. PTEN acetylation by PCAF block the ability of PTEN to downregulate PI3-K signalling and to induce G1 cell cycle arrest. PMID: 16829519

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Subcellular Location
Nucleus.
Protein Families
WD repeat TAF5 family
Database Links

HGNC: 17304

KEGG: hsa:27097

STRING: 9606.ENSP00000258281

UniGene: Hs.270621

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