TCN1 Antibody

Code CSB-PA023317LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023317LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TCN1 Polyclonal antibody
Uniprot No.
Target Names
TCN1
Alternative Names
Haptocorin antibody; Haptocorrin antibody; HC antibody; OTTHUMP00000235879 antibody; TC 1 antibody; TC I antibody; TC-1 antibody; TC1 antibody; TCI antibody; TCN 1 antibody; TCN1 antibody; TCO1_HUMAN antibody; Transcobalamin 1 antibody; Transcobalamin I antibody; Transcobalamin-1 antibody; Transcobalamin1 antibody; TranscobalaminI antibody; Vitamin B12 binding protein antibody; Vitamin B12 binding protein R binder family antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcobalamin-1 protein (24-433AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TCN1 Antibody (Product code: CSB-PA023317LA01HU) is Non-conjugated. For TCN1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA023317LB01HU TCN1 Antibody, HRP conjugated ELISA
FITC CSB-PA023317LC01HU TCN1 Antibody, FITC conjugated
Biotin CSB-PA023317LD01HU TCN1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
Gene References into Functions
  1. Higher placental TC protein abundance was associated with higher cord blood vitamin B12 concentrations, suggesting a potential role in vitamin B12 transport to the fetus. PMID: 27577703
  2. The variant rs526934 from the TCN1 gene was associated with an increased risk of developing gastric cancer. PMID: 26959381
  3. Levels of holotranscobalamin are decreased patients with cobalamin deficiency. PMID: 24057896
  4. Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin. PMID: 23846701
  5. TCN1 gene expression implicates disease progression in patient with middle ear cholesteatoma. PMID: 23670528
  6. comparison of human and rainbow trout cobalamin-binding protein PMID: 22872637
  7. Elevated concentrations of B(12) found in autoimmune lymphoproliferative syndrome patients were due to increased lymphocyte expression of haptocorrin. PMID: 22306884
  8. Stromal expression of KRT15, TCN1, and HOXB13 was significantly correlated with tumor grade, stromal hypercellularity, mitotic activity and microscopic borders. PMID: 21574054
  9. two novel mutations, each causing a premature stop codon - a genetic basis for TC I deficiency PMID: 19686235
  10. Comparative analysis of cobalamin binding kinetics PMID: 11788601
  11. No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease. PMID: 12590948
  12. interactions of COBALAMIN BINDING proteins with a number of ligands PMID: 17487979
  13. Maternal folate-related polymorphisms studied here (CBS, MTR, RFC-1, and TC) have no influence on trisomy 21 susceptibility in subjects of Brazilian population.v PMID: 19729796

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Subcellular Location
Secreted.
Protein Families
Eukaryotic cobalamin transport proteins family
Tissue Specificity
Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.
Database Links

HGNC: 11652

OMIM: 189905

KEGG: hsa:6947

STRING: 9606.ENSP00000257264

UniGene: Hs.2012

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