TESC Antibody

Datasheet

Code	CSB-PA023393GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q96BS2

Target Names

TESC

Alternative Names

TESC antibody; CHP3Calcineurin B homologous protein 3 antibody; Tescalcin antibody; TSC antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human TESC

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.

Gene References into Functions

This study found that the genotype of TESC at the rs7294919 locus and MDD had a significant interactive effect on the hippocampal subfield volume. PMID: 28575645
High Tescalcin expression is associated with colorectal cancer. PMID: 27485112
CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta phosphorylation. PMID: 25935310
This study demonstrated that highly significant effects of rs7294919 of tescalcin on hippocampal gray matter volumes. PMID: 24776739
a binding partner and regulator of subunit 4 of the COP9 signalosome PMID: 24659803
TESC is overexpressed in colorectal cancer PMID: 24811141
Loss of both N-myristoylation and calcium binding of CHP3 decreases cell surface stability of NHE1. PMID: 22984264
Tescalcin is one of the key gene products that is involved in switching differentiation program in some cell types. PMID: 20060826
CHP3 binds directly to the proximal juxtamembrane C-terminal region (amino acids 505-571) of rat NHE1 in the same region that binds CHP1 and CHP2. PMID: 18321853

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Subcellular Location

Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane.

Protein Families

Calcineurin regulatory subunit family, CHP subfamily

Tissue Specificity

Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.

Database Links

HGNC: 26065

OMIM: 611585

KEGG: hsa:54997

STRING: 9606.ENSP00000334785

UniGene: Hs.525709

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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