TESC Antibody

Code CSB-PA023393HA01HU
Size US$166
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  • Immunofluorescent analysis of A549 cells using CSB-PA023393HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Western blot
    All lanes: Calcineurin B homologous protein 3 antibody at 2μg/ml
    Lane 1: Hela whole cell lysate
    Lane 2: Mouse brain tissue
    Secondary
    Goat polyclonal to rabbit at 1/10000 dilution
    Predicted band size: 25, 19, 22 kDa
    Observed band size: 25 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TESC Polyclonal antibody
Uniprot No.
Target Names
TESC
Alternative Names
TESC antibody; CHP3Calcineurin B homologous protein 3 antibody; Tescalcin antibody; TSC antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Calcineurin B homologous protein 3 protein (2-214AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TESC Antibody (Product code: CSB-PA023393HA01HU) is Non-conjugated. For TESC Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA023393HB01HU TESC Antibody, HRP conjugated ELISA
FITC CSB-PA023393HC01HU TESC Antibody, FITC conjugated
Biotin CSB-PA023393HD01HU TESC Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA,WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Gene References into Functions
  1. This study found that the genotype of TESC at the rs7294919 locus and MDD had a significant interactive effect on the hippocampal subfield volume. PMID: 28575645
  2. High Tescalcin expression is associated with colorectal cancer. PMID: 27485112
  3. CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta phosphorylation. PMID: 25935310
  4. This study demonstrated that highly significant effects of rs7294919 of tescalcin on hippocampal gray matter volumes. PMID: 24776739
  5. a binding partner and regulator of subunit 4 of the COP9 signalosome PMID: 24659803
  6. TESC is overexpressed in colorectal cancer PMID: 24811141
  7. Loss of both N-myristoylation and calcium binding of CHP3 decreases cell surface stability of NHE1. PMID: 22984264
  8. Tescalcin is one of the key gene products that is involved in switching differentiation program in some cell types. PMID: 20060826
  9. CHP3 binds directly to the proximal juxtamembrane C-terminal region (amino acids 505-571) of rat NHE1 in the same region that binds CHP1 and CHP2. PMID: 18321853

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Subcellular Location
Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane.
Protein Families
Calcineurin regulatory subunit family, CHP subfamily
Tissue Specificity
Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
Database Links

HGNC: 26065

OMIM: 611585

KEGG: hsa:54997

STRING: 9606.ENSP00000334785

UniGene: Hs.525709

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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