THEMIS Antibody, Biotin conjugated

1. we have demonstrated mutually exclusive use of exon 1 and 2 amongst 16 novel THEMIS isoforms. We also show inverse correlation between THEMIS expression in human CD4+ T-cells and dosage of the multiple sclerosis risk allele at rs13204742, driven by reduced expression of exon 1- containing isoforms PMID: 27438997
2. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1. PMID: 28250424
3. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival. PMID: 25535246
4. THEMIS showed higher mRNA expression in active celiac disease compared with treated patients and controls. PMID: 23820479
5. THEMIS binding to GRB2 was required for thymocyte development. PMID: 23460737
6. Themis1 exhibits the same potential to restore T cell development and T cell receptor-mediated signaling in Themis1-deficient mice. PMID: 22732588
7. SPOP mutations may define a new molecular subtype of prostate cancer. PMID: 22610119
8. specific role for THEMIS in early TCR signalosome function PMID: 21189249
9. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
11. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20095854
12. Functional characterization of the homologous mouse gene. PMID: 19597498
13. Functional analysis of the mouse gene by knockout, and comparison of the mouse and human proteins. PMID: 19597499

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HGNC: 21569

OMIM: 613607

KEGG: hsa:387357

UniGene: Hs.661756