TIE1 Antibody, HRP conjugated

Code CSB-PA07369B0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TIE1 Polyclonal antibody
Uniprot No.
Target Names
TIE1
Alternative Names
JKT 14 antibody; JTK14 antibody; TIE antibody; Tie1 antibody; TIE1_HUMAN antibody; Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1 antibody; Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains antibody; Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 antibody; Tyrosine protein kinase receptor Tie 1 antibody; Tyrosine-protein kinase receptor Tie-1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tyrosine-protein kinase receptor Tie-1 protein (217-328AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Gene References into Functions
  1. We identified colorectal cancer as a novel Tie1-expressing tumor, with Tie1-positive cells hardly detectable in the normal intestine. Tie1 expression did not influence cancer cell proliferation in regular in vitro cultures, but significantly affected malignant growth of transplanted tumors in vivo. PMID: 28464467
  2. T794A-expressing human umbilical vein endothelial cells formed significantly shorter tubes with fewer branches in three-dimensional Matrigel cultures, but did not alter Tie1 or Tie2 tyrosine phosphorylation or downstream signaling. PMID: 26436659
  3. The decreasing expression of Tie1 may play an important role in the pathogenesis of primary lower extremity varicose veins. PMID: 22987233
  4. Data propose that EndMT associated with Tie1 downregulation participates in the pathological development of stroma observed in tumours. PMID: 22421998
  5. The Tie-1 immunoreactivity was dominantly observed in the heamangiogenic cells and cells cords, whereas the matured villi showed immunoreactivity only in other components. PMID: 20164029
  6. A natural antisense transcript was identified for tyrosine kinase containing immunoglobulin and epidermal growth factor homology domain-1 (tie-1), tie-1AS long noncoding RNA in zebrafish, mouse, and humans. PMID: 19880500
  7. high expression independently associated with shorter survival in patients with early chronic phase CML PMID: 11920509
  8. Overexpression and activation of Tie1 is associated with breast and colonic neopalsms PMID: 17786322
  9. the trophoblastic shell of the very early human placenta, as well as endothelial cells and ACC exhibited strong staining intensity for Tie-1 PMID: 18675456
  10. Tie-1 has an inflammatory function in endothelial cells. PMID: 19236867

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Protein kinase superfamily, Tyr protein kinase family, Tie subfamily
Tissue Specificity
Specifically expressed in developing vascular endothelial cells.
Database Links

HGNC: 11809

OMIM: 600222

KEGG: hsa:7075

STRING: 9606.ENSP00000361554

UniGene: Hs.78824

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