TIMM50 Antibody

Datasheet

Code	CSB-PA674736ESR2HU
Size	US$166
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Image	Western blot All lanes: TIMM50 antibody at 4.05µg/ml Lane 1: Rat heart tissue Lane 2: MM231 whole cell lysate Lane 3: MCF-7 whole cell lysate Lane 4: Hela whole cell lysate Lane 5: 293T whole cell lysate Lane 6: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 40, 51, 28 kDa Observed band size: 40 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA674736ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA674736ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TIMM50 Polyclonal antibody

Uniprot No.

Q3ZCQ8

Target Names

TIMM50

Alternative Names

TIMM50; TIM50; PRO1512; Mitochondrial import inner membrane translocase subunit TIM50

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Mitochondrial import inner membrane translocase subunit TIM50 protein (87-353AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.; May participate in the release of snRNPs and SMN from the Cajal body.

Gene References into Functions

Expression of TIM50 was downregulated in hypertrophic hearts. PMID: 28432072
Missense mutations in TIMM50 are likely manifesting by severe intellectual disability and epilepsy accompanied by 3-methylglutaconic aciduria and variable mitochondrial complex V deficiency. PMID: 27573165
TIM50 has a role in regulating cell proliferation and apoptosis through decreasing mitochondrial membrane potential in breast cancer cell PMID: 26289846
the interaction of divalent metal ions with the intermembrane space domain of Tim50 (Tim50(IMS)) and the interaction of presequence peptides with Tim50(IMS) in presence of Ca(2+) ion was investigated. PMID: 23098911
The far-UV CD spectra of Tim50(IMS) in native and denatured states revealed that the protein has a significantly folded secondary structure consisted of alpha-helixes and beta-sheets. PMID: 21742040
Tim50 regulates 3betaHSD2 expression and activity, representing a new role for translocases in steroidogenesis. PMID: 21930695
TIM50, was upregulated in a non-small cell lung carcinoma cell line (H1299) that expressed the p53 mutants R175H and R273H compared to cells lacking p53. PMID: 21621504
Tim50 is important for both mitochondrial function and early neuronal development PMID: 15044455
Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with coilin, snRNPs, and SMN PMID: 16008839

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Subcellular Location

Mitochondrion inner membrane; Single-pass membrane protein.; [Isoform 2]: Nucleus speckle.

Protein Families

TIM50 family

Tissue Specificity

Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level).

Database Links

HGNC: 23656

OMIM: 607381

KEGG: hsa:92609

STRING: 9606.ENSP00000318115

UniGene: Hs.590956

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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