TLR2 Antibody

Code CSB-PA023601LA01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TLR2 Polyclonal antibody
Uniprot No. O60603
Target Names TLR2
Alternative Names CD282 antibody; CD282 antigen antibody; TIL 4 antibody; TIL4 antibody; TLR 2 antibody; TLR2 antibody; TLR2_HUMAN antibody; Toll like receptor 2 antibody; Toll like receptor 2 precursor antibody; Toll-like receptor 2 antibody; Toll/interleukin 1 receptor like 4 antibody; Toll/interleukin 1 receptor like protein 4 antibody; Toll/interleukin receptor like protein 4 antibody; Toll/interleukin-1 receptor-like protein 4 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Toll-like receptor 2 protein (19-588AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides
Gene References into Functions
  1. TLR2 protein has a role in introduction of IL-6, IL-8, and TNF-alpha cytokines into human amniotic epithelial cells by Ureaplasma urealyticum-derived lipid-associated membrane proteins PMID: 30070088
  2. No significant association between TLR2 + 2477G/A polymorphism and bacterial meningitis risk were found under allele contrast, recessive genetic model. PMID: 29457581
  3. The detection of higher frequencies of the TLR2, TLR4 and/or TLR9 polymorphisms in colorectal cancer (CRC) patients compared with the control groups highlight the role of these polymorphism in CRC development and cancer progression PMID: 29883450
  4. These findings further validated the involvement of P. acnes in the pathology of intervertebral disc degeneration (IVDD) and provided evidence that P. acnes-induced apoptosis of NPCs via the TLR2/JNK pathway is likely responsible for the pathology of IVDD. PMID: 29323102
  5. Live Faecalibacterium prausnitzii, an abundant obligate anaerobe of the colonic microbiota, induced higher TLR2 and TLR2/6 activation than the dead bacterium. PMID: 29112296
  6. the results of the present study showed significantly higher mRNA expression levels for TLR2 180days post-transplantation in the graft dysfunction group compared to well functioning graft group PMID: 29452169
  7. Finding suggest that genetic variation in TLR2 (rs3804099) is associated with severity and prognosis of bacterial meningitis in Chinese children. PMID: 28202935
  8. The findings show that the expression of TLR2, TLR4 and TLR9, and hypoxia markers HIF-1alpha and CAIX is abnormal in pancreatic intraepithelial neoplasia suggesting that both the innate immunity activation and hypoxia response are involved in early pancreatic carcinogenesis. PMID: 30357962
  9. Results provide evidence regarding the association of the rs3804099 in the TLR2 gene with H. pylori infection and Peptic Ulcer. The rs3804099 may affect vulnerability to H. pylori infection, particularly to CagA+ strains of bacteria. PMID: 29755012
  10. Studied association of vitamin D receptor (VDR) single nucleotide polymorphisms (SNPs) and promoter region deletions of toll like receptor 2 (TLR2) with genetic predisposition for pulmonary tuberculosis (PTB) in India communities. Results show that the BsmI and FokI polymorphisms of the VDR gene are significantly associated with an increased risk of PTB. PMID: 29727015
  11. OLP changed the expression profile of miR-155 and miR-19a, which in turn directly affected the production of eNOS and TLR2, respectively. In addition, by synergistically inducing an imbalance between Th1 and Th2, the simultaneous deregulation of miR-155/eNOS and miR-19a/TLR2 was responsible for an elevated risk of OLP. PMID: 29813046
  12. Results suggested that TRL2 contributes to the development of atherosclerosis by regulating lipid accumulation, plaque formation and serum inflammatory cytokines level. PMID: 28815701
  13. Data suggest that serum levels of soluble TLR2 are down-regulated in subjects with type 2 diabetes as compared to control subjects; levels of soluble TLR4 are similar in both groups of subjects. PMID: 29160122
  14. our current findings demonstrate that TLR2 expression is upregulated in human colorectal cancer (CRC) tumor tissue and indicates poor prognosis. We show that TLR2 can promote CRC cellular proliferation concomitant with the upregulation of anti-apoptotic genes BCL2A1, WISP1 and BIRC3 subsequent to the activation of the PI3K/Akt and NF-kappaB signaling pathways. PMID: 29689497
  15. Genotyping was performed to detect -196 to -174 del polymorphism and G2258A SNP (Arg753Gln, rs5743708) in TLR2 gene in patients with pulmonary tuberculosis and healthy controls. We could not find a significant difference in allelic or genotypic frequencies of two TLR2 polymorphisms between cases and controls. PMID: 29675696
  16. Low TLR2 expression is associated with pancreatic ductal adenocarcinoma. PMID: 30246618
  17. Our results suggest that the R753Q polymorphism of the TLR-2 gene may be involved in the pathogenesis of mastocytosis. PMID: 29909409
  18. TLR2 SNPs were not associated with acute graft rejection in kidney transplant recipients. PMID: 28411360
  19. Heterozygote Arg753Gln TLR2 gene polymorphism was found in 9 of 86 pulmonary tuberculosis subjects (10.5%) but none in the latent TB group. Arg753Gln polymorphism of TLR2 gene is a risk factor for active pulmonary tuberculosis while Arg677Trp polymorphism is not. PMID: 29686176
  20. TLR2 Arg677Trp polymorphism and H. pylori infection may play crucial roles in peptic ulcer development respectively in north of Iran. PMID: 28844484
  21. CD44 regulated TLR2 responses in human macrophages, whereby a reduction in CD44 levels or engagement of CD44 by its ligand (HA) or a CD44-specific Ab reduced NF-kappaB translocation and downstream proinflammatory cytokine production. PMID: 29196459
  22. TLR2 up-regulation and TLR3 down-regulation occur in doxorubicin-treated patients who develop heart dysfunction. This may suggest a predictive role of TLR2-TLR3 imbalance in doxorubicin-induced heart failure. PMID: 29959987
  23. a crucial role of TLR2 depends on agonist release by bacterial surfactants, is reported. PMID: 27470911
  24. host gene variants in TLR2 signaling pathways were modestly associated with cervical A. vaginae in women with clinical pelvic inflammatory disease PMID: 29286178
  25. TLR2 may affect inflammatory reaction in coronary artery endothelial cells by introducing pro-inflammatory molecules like MyD88, pIRAK-1, and pNF-kappaB. PMID: 28986953
  26. A moderately truncated lipooligosaccharides (LOS) structure did not interfere with M. marinum invasion. However, a deeper shortening of the LOS structure was associated with increased entry of M. marinum into host cells and increased elimination of the bacilli by the macrophages. These effects were dependent on Toll-like receptor 2. PMID: 29183333
  27. Our results evidenced the deleterious effect of the Hap7 haplotype ([Del]-T-[M or L]) in the incidence rate in severe bacterial infections in pediatric SCA. This haplotype presents both the -196 to -174 22-bp deletion, localized in the TLR2 first untranslated exon, and the SNP rs4696480 T allele, in the TLR2 promoter, that have previously been associated with susceptibility to infections of various etiologies. PMID: 28667380
  28. A positive association between TLR2 polymorphisms and hepatitis B infection in a Han Chinese population. PMID: 29320990
  29. important factor in placental anti-parasite defenses, involved in the local secretion of cytokines but also in regulating, at least partially, the trophoblast turnover PMID: 29208238
  30. Mycobacterium tuberculosis protein MymA is a TLR2 agonist that upregulates signaling via MyD88 and NF-kappaB in macrophages to stimulate the release of proinflammatory cytokines PMID: 28802400
  31. Data showed strong interactions of toll-like receptors TLR2 and 4 associated with Leishmania(V.) braziliensis, while toll-like receptor TLR9, in contrast, a strong interaction with Leishmania (L.) amazonensis. PMID: 29543867
  32. Lsa21 is a potent TLR2 and TLR4 agonist that induces strong innate response and may play important role in Leptospira pathogenesis PMID: 27996041
  33. No significant association between polymorphisms of TLR2 and TLR4 with pulmonary tuberculosis or latent tuberculosis infection was detected. PMID: 29924447
  34. ionizing radiation increased the cell surface expressions of TLR2 and TLR4 through reactive oxygen species-mediated JNK activation. PMID: 28369600
  35. the TLR2-196 to -174 Ins/Del polymorphism is a risk factor for HIV-1 transmission in HIV-1 infected North Indian individuals. PMID: 28730622
  36. TLR-2 transcript is significantly up-regulated in the tissue of intracranial aneurysm. PMID: 29066233
  37. TLR2 signaling is important to control the fungal burden in the vaginal tract. These finding provide new evidence about the role of this innate receptor during vulvovaginal candidiasis. PMID: 28911197
  38. Variant A of the SNP TLR2-rs4696480 polymorphism significantly increased the risk of OSCC (p = 0.03) and OLL (p = 0.02). PMID: 28624699
  39. Expression of TLR2 and TLR4 may be affected by the type of bacteria that are present in the gut. PMID: 29085211
  40. Identification of TLR2/TLR6 signalling lactic acid bacteria for supporting immune regulation. PMID: 27708357
  41. Studied associations of 12 single nucleotide polymorphisms (SNPs) within toll like receptor genes (TLR2, TLR3, TLR4, and TLR9) and genetic predisposition to neonatal severe hepatitis. Found certain SNPS were associated with prognosis of neonatal severe hepatitis. PMID: 28703296
  42. High Expressions of TLR2 is associated with degenerative knee osteoarthritis. PMID: 28418842
  43. The TLR2 (R753Q and A-16934T) single nucleotide polymorphisms are not associated with atopic dermatitis in a group of Turkish patients PMID: 28443596
  44. results implicate neuronal TLR2 expression in human Parkinson's disease pathogenesis PMID: 27888296
  45. this study signifies that TLR2 adaptor molecules are necessary for the proper production of cytokines, chemokines and pro-labour mediators after TLR ligation PMID: 28844021
  46. results indicate that although live B. anthracis and S. aureus express abundant TLR2 ligands, highly-purified PGN from either bacterial source is not recognized by TLR2. PMID: 29474374
  47. TLR2 and BGN contribute to sterile inflammation and infertility in man. PMID: 27849015
  48. Data show that infecting unencapsulated E. faecalis cps2 is a stronger stimulator for toll like receptor 2 (TLR2) and interleukin-1beta (IL-1beta) mRNAs, but not for inducible nitric oxide synthase (iNOS) mRNA. PMID: 28800779
  49. In the majority of cosmonauts increases in endogenous ligands were followed by growth in the number of both monocytes and granulocytes that express TLR2 and TLR4. PMID: 29553590
  50. These data suggest that TLR2 activation is involved in the induction of IL-15 production by primary Sjogren's syndrome salivary gland epithelial cells and promotes inflammation through NF-kappaB activation. PMID: 27260411
  51. polymorphism of TLR2 locus is associated with risk of sporadic PD in the North-eastern part of Han Chinese population PMID: 28729076
  52. NOD2 up-regulates TLR2-mediated IL-23p19 expression via increasing c-Rel activation in Paneth cell-like cells PMID: 27563808
  53. hypomethylation of the TLR2 promoter, particularly CpG6, was associated with the risk of EH in this population. Additionally, a genegene interaction between CpG6 and CpG8, and interactions between environmental factors, including smoking and alcohol consumption, and CpG6, CpG7 and CpG8, may be associated with the risk of EH. PMID: 28560381
  54. this study shows that increased expression of TLR2 is associated with reduced DNA methylation in spontaneous preterm labor PMID: 28622534
  55. Our results suggest that the carrier status for the GA variant of the TLR2 Arg753Gln (rs5743708) polymorphism may be a risk factor for Staphylococcus aureus carriage. PMID: 28518213
  56. recombinant NS1, expressed and purified from eukaryotic cells, induces cytokine production via TLR4 but not TLR2/6. PMID: 28220810
  57. The minor alleles of TLR2-rs3775290, TLR4-rs7873784, and TLR9-rs352140, and interaction between rs352140 and HPV infection were all associated with increased cervical cancer risk. PMID: 28497211
  58. Studies assess the role of TLR2 and TLR4 gene expression as an early marker for the risk of doxorubicin-induced cardiomyopathy. PMID: 28256509
  59. This study revealed that TLR2 rs3804100 and TLR3 rs3775291 polymorphisms may be protective factors for HBV-related hepatocellular carcinoma . PMID: 28009434
  60. TLR2 polymorphism is associated with Toxoplasma gondii infection. PMID: 28500897
  61. These findings suggest that the activation of TLR2 by bacterial components can enhance the progression of OSCC and may be implicated in acquired resistance to cisplatin-induced apoptosis through regulation of the miR-146a pathway. PMID: 29269299
  62. Cerebrospinal fluid soluble TLR2 and TLR4 may play a role in HIV/SIV-related neuroinflammation and subsequent neuropathology. PMID: 27882497
  63. Following a combined in silico/in vitro approach we have discovered TLR2-agonists (AG1-AG4) that activate human and mouse immune cells. PMID: 28734965
  64. PBMC TLR2 and TLR4 were significantly higher in the AFMI group than in the control group and MI group. A similar tendency was also oTLR4 proteinbserved in the expression of downstream signaling proteins. When further analyzed with TLR2 and TLR4 antibodies by flow cytometry, PBMC levels also appeared to be higher in AFMI patients than those in MI patients and the healthy control group.In our study PMID: 29375116
  65. analysis of TLR2 rs5743708, TLR2 rs4696480, TLR4 rs4986790, TLR9 rs5743836 and TLR9 rs352140 SNPs in children with pneumococcal and meningococcal meningitis and their family members; study did not show an association between the analyzed SNPs in TLR2, TLR4, and TLR9 and susceptibility to develop bacterial meningitis PMID: 28487240
  66. TLR2 and IL28B polymorphisms in combination showed a role in the control of HCV viral load and different HCV disease progression. PMID: 27183918
  67. Data suggest that dendritic cells are sensitive to environmentally relevant level of aflatoxin B1 (AFB1); TLR2 and TLR4 are involved in sensing AFB1; expression levels of both TLR2 and TLR4 mRNA and proteins were significantly up-regulated in AFB1-treated dendritic cells. PMID: 24626284
  68. HBsAg simulation increased proinflammatory cytokine production and invasion of HepG2.2.15 cells, while this process was inhibited by TLR2 silence. PMID: 28061318
  69. this review highlights the contribution of TLR2 to host protection, immune evasion by Mycobacterium tuberculosis and immune regulation during chronic Mycobacterium tuberculosis infection PMID: 27326654
  70. treatment with an antibody against Toll-like receptor (TLR) 2 reversed the effect of L. paracasei on inducing negative regulators and inhibiting TNF-alpha and IL-1beta productions. PMID: 28088611
  71. Neonatal cells were more potent in the activation of ERK and Akt through TLR2 and TLR4 co-activation. PMID: 27380627
  72. T. denticola stimulates the innate immune system in a TLR2-dependent fashion. PMID: 29084899
  73. This study shows TLR2 signalling induce cytokine production and regulate wnt signalling thereby cause maturation of megakaryocyte. PMID: 27179140
  74. Taken together, the data presented here suggest that TLR2 activation in human mast cells promotes the release of inflammatory mediators via distinct signaling pathways that partially depend on the action of Go proteins. PMID: 27515449
  75. elevated expression of TLR2 on CD14+ monocytes in pulmonary tuberculosis patients confirms the role of TLR2 in host defense against M. tuberculosis. 597T/C polymorphism of TLR 2 gene may be a risk factor for susceptibility to pulmonary tuberculosis in a sample Egyptian population. PMID: 28502147
  76. study to examine potential associations between a selection of SNPs in the genes encoding TLR2 and TOLLIP, and predisposition, severity and outcome of Staphylococcus aureus bloodstream infections (SABSI); the TLR2 and TOLLIP polymorphisms were not associated with susceptibility to SABSI, severity, 30-day all-cause mortality, or SABSI caused by the clonal complex 30 genotype PMID: 28736863
  77. Biglycan stimulation of endothelial cells increased the interaction between NF-kB and the HIF-1alpha promoter, leading to enhanced promoter activity and increased HIF-1alpha mRNA levels, as well as augmented HIF-1 activity that resulted in VEGF expression PMID: 27590684
  78. Only the TLR2 +596 SNP was found to be significantly associated to asthma (OR = 3.24 for CT, 2.71 for TT) and particularly to females. The identification of TLR SNPs will reveal potential candidates for gene-environment interactions in Puerto Ricans. PMID: 27495363
  79. relative frequency of TLR2 polymorphism was similar in heart transplant (HTX) patients and blood donors; TLR2 polymorphism was neither associated with occurrence or level of cytomegalovirus (CMV) infection nor with survival, graft failure or rejection, or CMV serostatus of patient before transplantation PMID: 27723526
  80. this study shows that neutrophil expression levels of TLR2 are increased in septic patients PMID: 27016001
  81. in this study using TLR2 and TLR4-reporter cells, lipoproteins were found to inhibit TLR responses with differences in affinity and kinetics PMID: 27793087
  82. High TLR2 expression is associated with gastric cancer. PMID: 28481875
  83. Data suggest that anti-inflammatory effects of DHA (and inflammatory effects of palmitic acid) are at least in part mediated through modulating ER homeostasis; ER stress can be differentially modulated by various types of dietary fat; DHA down-regulates ligand-induced activation of TLR2 and TLR4 in activated monocytes. (DHA = docosahexaenoic acid; ER = endoplasmic reticulum; TLR = toll-like receptor) PMID: 27142735
  84. these results reveal a novel role of T-cell expressed TLR2 in enhancing the differentiation and function of TH9 T cells PMID: 28665005
  85. TLR2 plays a key role in platelet hyperreactivity and the prothrombotic state in the setting of hyperlipidemia by sensing a wide range of endogenous lipid peroxidation ligands and activating innate immune signaling cascade in platelets. PMID: 28775078
  86. These data illustrate a functional role for TLR2 in the pathogenesis of choroidal neovascularization. PMID: 28739342
  87. The combined results of this meta-analysis show that rs3804099 in TLR2 and rs4986791 in TLR4 were significantly associated with asthma risk PMID: 28858111
  88. aim of the current review article is to present recent data regarding the roles of Toll-like receptor 2 in induction of immune responses and consequently eradication of Legionella pneumophila. PMID: 28887059
  89. of a role for TLRs expression in tuberculous PE PMID: 28494727
  90. two functional relevant polymorphisms in TLR2, the GTn microsatellite repeat polymorphism in intron 2 and the Arg753Gln variant do not seem to play a role in the susceptibility to Crohn's disease or ulcerative colitis PMID: 28388655
  91. IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta responses in a TLR2- and FcgammaR-dependent fashion. PMID: 27365531
  92. Estradiol alters the immune-responsiveness of cultured HECECs to TLR2 and TLR4 ligands in a complex fashion that appears to vary with bacterial ligand, TLR subtype, and duration of exposure PMID: 28296959
  93. salt-inducible kinase inhibition decreases proinflammatory cytokines in human myeloid cells upon IL-1R stimulation. PMID: 26590148
  94. Among various TLR2, TLR4 and TLR9 polymorphisms, TLR2 2258 G/A single nucleotide polymorphism seems to be an important factor associated with increased risk of congenital human cytomegalovirus infection in Polish fetuses and neonates. PMID: 28118851
  95. these findings identify new compounds for antagonizing TLR2 and TLR4 activation and define structural properties of POPG analogs for discriminating between two TLR systems. PMID: 27095543
  96. results indicate that rhinovirus (RV) stimulates CXCL-10 expression via the IL-33/ST2 signaling axis, and that TLR2 signaling limits RV-induced CXCL-10 via IRAK-1 depletion at least in airway epithelial cells PMID: 27503209
  97. The combination of glucocorticosteroids with TLR ligands can increase TLR2 expression in alveolar macrophages, thereby improving host defense in smokers. PMID: 27274225
  98. TLR2 polymorphism may contribute to the pathogenesis of AMD. PMID: 26398587
  99. The mRNA levels of Toll-like receptors TLR2, 6, and 9 were significantly elevated in the Kawasaki disease (KD) patient group versus the healthy controls. PMID: 28061462
  100. TLR2 signaling is very likely impaired in patients with fulminant form of hepatitis B-related acute liver failure. The recurrence of rare case-specific TLR2 variant strongly suggests mechanistic contribution to fulminancy in HBV infection. PMID: 28329297

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Subcellular Location Membrane, Single-pass type I membrane protein, Cytoplasmic vesicle, phagosome membrane, Single-pass type I membrane protein, Membrane raft
Protein Families Toll-like receptor family
Tissue Specificity Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
Database Links

HGNC: 11848

OMIM: 246300

KEGG: hsa:7097

STRING: 9606.ENSP00000260010

UniGene: Hs.519033

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