TLR2 Antibody, Biotin conjugated

Datasheet
Code CSB-PA023601LD01HU
Size US$299
Uniprot No. O60603
Immunogen Recombinant Human Toll-like receptor 2 protein (19-588AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282), TLR2, TIL4
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Immunology
Target Names TLR2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides
Subcellular Location Membrane, Single-pass type I membrane protein, Cytoplasmic vesicle, phagosome membrane, Single-pass type I membrane protein, Membrane raft
Protein Families Toll-like receptor family
Tissue Specificity Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
Database Links

HGNC: 11848

OMIM: 246300

KEGG: hsa:7097

STRING: 9606.ENSP00000260010

UniGene: Hs.519033

Pathway PI3K-Akt signaling pathway
Toll-like receptor signaling pathway

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