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| Code | CSB-EP023601HU1 |
| Product Type | Recombinant Protein |
| Size | US$1726 |
| Uniprot No. | O60603 |
| Relevance | Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | Toll/interleukin-1 receptor-like protein 4; CD282 |
| Species | Homo sapiens (Human) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | KEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRT |
| Research Area | Immunology |
| Source | E.coli |
| Gene Names | TLR2 |
| Expression Region | 19-588aa |
| Tag Info | N-terminal 6xHis-SUMO-tagged |
| Mol. Weight | 80.4kDa |
| Protein Description | Partial |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides |
| Subcellular Location | Membrane, Single-pass type I membrane protein, Cytoplasmic vesicle, phagosome membrane, Single-pass type I membrane protein, Membrane raft |
| Protein Families | Toll-like receptor family |
| Tissue Specificity | Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. |
| Database Links |
HGNC: 11848 OMIM: 246300 KEGG: hsa:7097 STRING: 9606.ENSP00000260010 UniGene: Hs.519033 |
| Pathway |
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway |
TLR2 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA023601LD01HU | TLR2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA023601LC01HU | TLR2 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA023601LB01HU | TLR2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023601LA01HU | TLR2 Antibody | Human | ELISA |
| CSB-PA080185 | TLR2 Antibody | Human,Mouse,Rat | IHC,ELISA |
| CSB-PA205006 | TLR2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA183593 | TLR2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA449240 | TLR2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA064553 | TLR2 Antibody | Human,Mouse | ELISA,WB,IHC |
TLR2 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP023601HU1 CSB-BP023601HU1 CSB-MP023601HU1 |
Recombinant Human Toll-like receptor 2(TLR2), partial | Yeast Baculovirus Mammalian cell |
| CSB-CF023601HU | Recombinant Human Toll-like receptor 2(TLR2) | in vitro E.coli expression system |
TLR2 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E11781h | Human toll-like receptor 2,TLR2 ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
Recombinant Human ATP-binding cassette sub-family D member 1(ABCD1) (Active)
Express system: in vitro E.coli expression system
Species: Homo sapiens (Human)
Recombinant Human Basic leucine zipper and W2 domain-containing protein 2(BZW2) (Active)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Proprotein convertase subtilisin/kexin type 5(Pcsk5),partial
Express system: Yeast
Species: Mus musculus (Mouse)
Recombinant Mouse Interleukin-2 receptor subunit beta(Il2rb),partial
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human Early growth response protein 1(EGR1),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Transcription activator BRG1(SMARCA4),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Biliverdin reductase A(BLVRA)
Express system: E.coli
Species: Homo sapiens (Human)
