TLR5 Antibody, FITC conjugated

Code CSB-PA023604LC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TLR5 Polyclonal antibody
Uniprot No. O60602
Target Names TLR5
Alternative Names FLJ10052 antibody; MGC126430 antibody; MGC126431 antibody; SLEB1 antibody; TIL 3 antibody; TIL3 antibody; TLR 5 antibody; Tlr5 antibody; TLR5_HUMAN antibody; Toll like receptor 5 antibody; Toll like receptor 5 precursor antibody; Toll-like receptor 5 antibody; Toll/interleukin 1 receptor like protein 3 antibody; Toll/interleukin-1 receptor-like protein 3 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Toll-like receptor 5 protein (682-850AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life.
Gene References into Functions
  1. SNPs associated with genetically determined high activity of TLR5 among patients with CD and genetically determined high IL-12 and IL-18 levels among patients with UC. PMID: 28139755
  2. results suggest that Hsp90 inhibitors suppress TLR5 surface expression and activation of NF-kappaB in THP-1 cells in response to TLR5 ligand, and these inhibitory effects may be associated with the possible mechanisms by which Hsp90 inhibitors suppress myeloid leukemia. PMID: 29651431
  3. this study signifies that TLR5 adaptor molecules are necessary for the proper production of cytokines, chemokines and pro-labour mediators after TLR ligation PMID: 28844021
  4. the newly found long TLR5 transcripts may be involved in the negative regulation of TLR5 expression and function. PMID: 28948171
  5. It was observed that the TLR5 polymorphisms rs5744168, rs2072493, and rs5744174 are less frequent in Indian Tamils, suggesting that the TLR5 gene remains conserved, which may be due to the genetic selection pressure to withstand prevailing endemic infectious diseases. We observed that these polymorphisms also failed to confer significant risk to develop chronic H. pylori infections and its associated clinical phenotypes PMID: 28742407
  6. we identified significant interactions between TLR5 rs1640827, rs17163737 and Helicobacter pylori infection. This results provide valuable insights into the TLR5 and Helicobacter pylori infection involved in gastric carcinogenesis, and this may have important implications in personalized prevention of GC. PMID: 28404962
  7. TLR 5, 7, and 9 expression patterns differed between HPV-positive and -negative oropharyngeal squamous cell carcinoma patients. In HPV-positive tumors the expression of TLR 5 and 7 correlated with tumor recurrence. PMID: 28856441
  8. These results suggest that HMGB1-modulated TLR5 signaling is responsible for pain hypersensitivity. PMID: 27760316
  9. data show that TLR-5 and TLR-9 are susceptible genes to lupus nephritis (LN) and that their expression is dysregulated in LN patients' kidneys, supporting a role of these mediators in the pathogenesis of LN. PMID: 28763101
  10. These results indicate that in Chinese genetic variation of TLR5 may be not a determinant of susceptibility to hepatitis B virus-related diseases but may play a role in development of hepatitis B virus-related severe liver diseases. PMID: 28543911
  11. Distinctive Recognition of Flagellin by Human and Mouse Toll-Like Receptor 5 PMID: 27391968
  12. This study independently confirms the association of TLR5 c.1174C>T with protection against death in melioidosis, identifies lower bacteremia, IL-10 and TNF-alpha production in carriers of the variant with melioidosis. PMID: 28475641
  13. Study demonstrated that toll-like receptor 5 expression and functional activity as measured by interleukin 6 are modulated by hormones PMID: 27651177
  14. findings suggest that TLR5 is functionally expressed in the SG and responds to its cognate ligand flagellin PMID: 27665969
  15. that TLR5 is involved in the pathogenesis and dissemination of esophageal adenocarcinoma through as-yet-uncharacterized mechanisms PMID: 27392931
  16. Ligands for TLR1/2 or TLR5 may provide critical stimuli able to sustain the growth and the malignant phenotype of MCL cells. PMID: 27123851
  17. The distribution of the TLR 5 genotypes did not differ significantly between bronchopulmonary dysplasia patients and controls. PMID: 27457283
  18. Both TLR 5 and 7 are expressed in salivary adenoid cystic carcinoma on the cell membranes as well as in cytoplasm. PMID: 26888781
  19. The results of this study demonstrated that TLR5 rs5744174 polymorphism may have no impact on the stroke risk, gene expression and inflammatory cytokines, but may influence the HDL-C serum level of IS patients in Chinese Han population. PMID: 27262705
  20. Letter: TLR5 mRNA was not altered in peripheral mononuclear cells from patients with ankylosing spondylitis or rheumatoid arthritis. PMID: 26996117
  21. These results indicate that in response to Pseudomonas aeruginosa or flagellin, EGFR associates with and tyrosine phosphorylates MUC1-CT in primary normal human bronchial epithelial cells, leading to increased MUC1-CT association with TLR5 PMID: 26645913
  22. Study elucidated the relationship between TLR5 and caveolin-1 at the transcriptional and translational levels using human cells, results suggest that caveolin-1 is a crucial regulator for maintaining and controlling TLR5 expression. PMID: 26615831
  23. Study showed that MyD88 Toll/interleukin-1 receptor (TIR) domain interacted with TLR5TIR but not with TLR6TIR. The solubility of both TLR5TIR and TLR6TIR were influenced by its binding partner MyD88TIR. Moreover, TLR5TIR exhibited increased solubility. PMID: 26548862
  24. TLR-5 was more abundant in OSCC than in CSCC samples. PMID: 25047824
  25. genetic polymorphism is not associated with duodenal ulcer PMID: 25995217
  26. p53-dependent amplification of transcriptional response to TLR5 activation required expression of NFkappaB subunit p65 and was mediated by several molecular mechanisms PMID: 26220208
  27. TLR5 variants R392X and N592S showed significant association with UC patients but TLR 1, 2, 3, 6 variants did not show any association. PMID: 25789623
  28. Studies indicate that toll-like receptor 5 (TLR5) specifically interacts with flagellin, and is useful as an analytical recognition element for low concentrations of flagellin. PMID: 24881544
  29. review of recent research on the interactions between TLR5, adaptive immunity and the microbiota; discussion of how variation in the TLR5 gene may alter these interactions to impact host inflammatory phenotypes in humans PMID: 25284610
  30. Establishing bacterial flagellin-recognizing toll-like receptor 5 (TLR5) as a novel link between gut microbiota composition, adipose tissue inflammation, and obesity. PMID: 25611816
  31. Flagellin activated TLR5 protein in non-small cell lung cancer cell lines and initiate downstream signaling pathways. PMID: 25603867
  32. mediates cytokine production in response to the Toxoplasma gondii-derived profilin PMID: 24861338
  33. Association of TLR5 Gene Polymorphisms in Ulcerative Colitis Patients of North India and Their Role in Cytokine Homeostasis. PMID: 25789623
  34. Study demonstrates that TLR5 recognition of commensal microbiota regulates systemic tumor-promoting inflammation and, subsequently, extramucosal malignant progression. PMID: 25533336
  35. A family was heterozygous for risk variants of the genes encoding NOD2 and TLR5 and homozygous carriers of PTPN2 risk alleles in Crohn disease. PMID: 24901824
  36. Genetic polymorphisms in TLR5 might be associated with decreased susceptibility of Graves' disease in Chinese Cantonese females. PMID: 24830583
  37. results reveal broad expression patterns of TLR5 and TLR7 in the lung and that the expression is decreased in severe asthma. PMID: 24447081
  38. TLR5 activation by flagellin may elicit chemoresistance in Multiple myeloma patients who have suffered from recurrent bacterial infections. PMID: 24709011
  39. Sle1 transgene perturbs the action of peripheral tolerance checkpoints operative on antinuclear antigen B cells in both the antibody-forming cell and germinal center pathways in a cell autonomous fashion. PMID: 19828626
  40. TLR5(rs5744105)variant was associated with altered immune responses in very low birth weight infants (elevated WBC counts)during bacterial infections. PMID: 23867959
  41. Frequent SNP's in the flagellin receptor TLR5 and the TLR downstream effector molecules MyD88 and TIRAP that are associated with altered survival in a large cohort of Caucasian patients with colorectal cancer PMID: 24154872
  42. Low expression of TLR5 was associated with non-small cell lung cancer. PMID: 24549739
  43. Authors suggest that TLR5 is involved in host defense against Aspergillus fumigatus, and that the recipient TLR5-Stop SNP represents a risk factor for the development of invasive aspergillosis after allogeneic stem cell transplantation. PMID: 23862689
  44. suggest a role for abnormal expression of TLR5 in the pathogenesis of esophageal adenocarcinoma and suggest importance of altered microbiome in the pathogenesis of complications of Barrett's esophagus PMID: 24221343
  45. exposure of human T cells to flagellin leads to a transient TLR5-induced increase in the sensitivity of these cells to subsequent TCR activation. PMID: 24128895
  46. TLR5 signaling enhances the proliferation of human allogeneic CD40-activated B cell induced CD4hiCD25+ regulatory T cells. PMID: 23844139
  47. These results indicate that polyethylenimine is a new TLR5 agonist with potential application in offering protection for patients receiving radiotherapy or in radiation-related accidents. PMID: 23104900
  48. A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin. PMID: 23593463
  49. Our data demonstrate a novel role for TLR-5 in rheumatoid arthritis angiogenesis; thus, TLR-5 may be a promising new target for its treatment. PMID: 23666857
  50. Data indicate the biological activity of a TLR5:flagellin complex with a 2:2 stoichiometry. PMID: 23624387

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Involvement in disease Systemic lupus erythematosus 1 (SLEB1)
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Protein Families Toll-like receptor family
Tissue Specificity Highly expressed on the basolateral surface of intestinal epithelia. Expressed also in other cells such as lung epithelial cells.
Database Links

HGNC: 11851

OMIM: 109100

KEGG: hsa:7100

STRING: 9606.ENSP00000340089

UniGene: Hs.604542

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