TNK1 Antibody

Datasheet

Code	CSB-PA024002GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q13470

Target Names

TNK1

Alternative Names

TNK1 antibody; Non-receptor tyrosine-protein kinase TNK1 antibody; EC 2.7.10.2 antibody; CD38 negative kinase 1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human TNK1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

Gene References into Functions

The activated TNK1 potentiates JAK-STAT signaling through dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino acid positions. PMID: 24449862
The application of functional genomics by using high-throughput-RNAi screens has allowed us to identify TNK1 as a growth-associated kinase in pancreatic cancer cells. PMID: 21536687
Activated Tnk1 kinase is associated with Hodgkin's lymphoma. PMID: 20090780
TNK1 therefore acts as a novel molecular switch that can determine the properties of TNFalpha signaling and therefore cell death. PMID: 17471239

Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein.

Protein Families

Protein kinase superfamily, Tyr protein kinase family

Tissue Specificity

Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small in

Database Links

HGNC: 11940

OMIM: 608076

KEGG: hsa:8711

STRING: 9606.ENSP00000312309

UniGene: Hs.203420

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Protein Kinases Overview: Definition, Types, Function, Activation Mechanism, etc. Protein Tyrosine Kinases: Anti-tumor Targets to be Explored Urgently Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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