TNMD Antibody

Code CSB-PA024007LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western Blot
    Positive WB detected in: Mouse heart tissue
    All lanes: TNMD antibody at 2.8μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 38, 24, 31 kDa
    Observed band size: 38 kDa

  • Immunofluorescent analysis of HepG2 cells using CSB-PA024007LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TNMD Polyclonal antibody
Uniprot No. Q9H2S6
Target Names TNMD
Alternative Names BRICD4 antibody; BRICHOS domain containing 4 antibody; CHM1 LIKE antibody; ChM1L antibody; Chondromodulin I like antibody; Chondromodulin I like protein antibody; Chondromodulin-1-like protein antibody; Chondromodulin-I-like protein antibody; hChM1L antibody; hTeM antibody; Myodulin antibody; TeM antibody; Tendin antibody; Tenomodulin antibody; Tenomodulin protein antibody; Tnmd antibody; TNMD_HUMAN antibody; UNQ771/PRO1565 antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Tenomodulin protein (131-254AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells. T Iwata,J. Periodont. Res,2020

Applications: Western blot analysis
Antibody dilution factor: 1:1000
Review: TNMD protein expression determined by western blotting. Band densities were measured by image analysis. Values represent band densities (mean ± SD) relative to non-target control miRNA inhibitor–treated cells (NC) on day 0.
PMID: 32797637

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Target Data

Function May be an angiogenesis inhibitor.
Gene References into Functions
  1. our study demonstrates that Tnmd is required for proper tendon tissue adaptation to endurance running and aids in better understanding of the structural-functional relationships of tendon tissues. PMID: 28566251
  2. TNMD is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive individuals. TNMD expression increases in human preadipocytes during differentiation, whereas silencing TNMD blocks adipogenesis. PMID: 26880110
  3. results suggest that Tnmd acts on the maturation or maintenance of the PDL by positively regulating cell adhesion via its BRICHOS domain PMID: 23593173
  4. Report differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin and suggest possible roles in tenocyte proliferation and tendon injury. PMID: 22700804
  5. According to these results the sequence variation of TNMD is not associated with alzheimer disease, but might modify the effect of APOE epsilon4-allele in women. PMID: 19524323
  6. Polymorphisms are associated with adiposity and also with glucose metabolism and conversion from glucose intolerance to type 2 diabetes. PMID: 17495183
  7. Tenomodulin is expressed abundantly in the elastin-rich subendothelial outer layer of the normal chordae tendineae cordis. PMID: 18838562
  8. TNMD could be a novel candidate gene for age-related macular degeneration. PMID: 19381347
  9. Human adipose tissue TNMD gene expression is highly affected by obesity, adipose tissue location, and weight loss, indicating that TNMD may play a role in adipose tissue function. PMID: 19602561

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Subcellular Location Isoform 1: Membrane, Single-pass type II membrane protein, Nucleus envelope, SUBCELLULAR LOCATION: Isoform 2: Membrane, Single-pass type II membrane protein, Nucleus envelope, SUBCELLULAR LOCATION: Isoform 3: Cytoplasm
Protein Families Chondromodulin-1 family
Tissue Specificity Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.
Database Links

HGNC: 17757

OMIM: 300459

KEGG: hsa:64102

STRING: 9606.ENSP00000362122

UniGene: Hs.132957

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