TNMD Antibody, FITC conjugated

Code CSB-PA024007LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TNMD Polyclonal antibody
Uniprot No.
Target Names
TNMD
Alternative Names
BRICD4 antibody; BRICHOS domain containing 4 antibody; CHM1 LIKE antibody; ChM1L antibody; Chondromodulin I like antibody; Chondromodulin I like protein antibody; Chondromodulin-1-like protein antibody; Chondromodulin-I-like protein antibody; hChM1L antibody; hTeM antibody; Myodulin antibody; TeM antibody; Tendin antibody; Tenomodulin antibody; Tenomodulin protein antibody; Tnmd antibody; TNMD_HUMAN antibody; UNQ771/PRO1565 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Tenomodulin protein (131-254AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May be an angiogenesis inhibitor.
Gene References into Functions
  1. our study demonstrates that Tnmd is required for proper tendon tissue adaptation to endurance running and aids in better understanding of the structural-functional relationships of tendon tissues. PMID: 28566251
  2. TNMD is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive individuals. TNMD expression increases in human preadipocytes during differentiation, whereas silencing TNMD blocks adipogenesis. PMID: 26880110
  3. results suggest that Tnmd acts on the maturation or maintenance of the PDL by positively regulating cell adhesion via its BRICHOS domain PMID: 23593173
  4. Report differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin and suggest possible roles in tenocyte proliferation and tendon injury. PMID: 22700804
  5. According to these results the sequence variation of TNMD is not associated with alzheimer disease, but might modify the effect of APOE epsilon4-allele in women. PMID: 19524323
  6. Polymorphisms are associated with adiposity and also with glucose metabolism and conversion from glucose intolerance to type 2 diabetes. PMID: 17495183
  7. Tenomodulin is expressed abundantly in the elastin-rich subendothelial outer layer of the normal chordae tendineae cordis. PMID: 18838562
  8. TNMD could be a novel candidate gene for age-related macular degeneration. PMID: 19381347
  9. Human adipose tissue TNMD gene expression is highly affected by obesity, adipose tissue location, and weight loss, indicating that TNMD may play a role in adipose tissue function. PMID: 19602561

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Subcellular Location
[Isoform 1]: Membrane; Single-pass type II membrane protein. Nucleus envelope.; [Isoform 2]: Membrane; Single-pass type II membrane protein. Nucleus envelope.; [Isoform 3]: Cytoplasm.
Protein Families
Chondromodulin-1 family
Tissue Specificity
Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.
Database Links

HGNC: 17757

OMIM: 300459

KEGG: hsa:64102

STRING: 9606.ENSP00000362122

UniGene: Hs.132957

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