TPM3 Antibody

Code CSB-PA024106GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TPM3
Alternative Names
Alpha tropomyosin 3 antibody; Alpha tropomyosin slow skeletal antibody; CFTD antibody; Cytoskeletal tropomyosin TM30 antibody; FLJ41118 antibody; gamma TM antibody; Gamma tropomyosin antibody; Gamma-tropomyosin antibody; Heat stable cytoskeletal protein 30 kDa antibody; hscp30 antibody; hTM30nm antibody; hTM5 antibody; hTMnm antibody; MGC102590 antibody; MGC14582 antibody; MGC3261 antibody; MGC72094 antibody; NEM1 antibody; OK/SW-cl.5 antibody; OTTHUMP00000034019 antibody; OTTHUMP00000034171 antibody; OTTHUMP00000034172 antibody; TM 5 antibody; TM-5 antibody; TM3 antibody; TM30 antibody; TM30nm antibody; TM5 antibody; Tm5NM antibody; Tpm 5 antibody; TPM3 antibody; TPM3/NTRK1 FUSION GENE, INCLUDED antibody; TPM3_HUMAN antibody; Tpm5 antibody; TPMsk3 antibody; TRK antibody; TRK ONCOGENE, INCLUDED antibody; Trop 5 antibody; Tropomyosin 3 antibody; Tropomyosin 3 gamma antibody; Tropomyosin 5 antibody; Tropomyosin alpha 3 chain antibody; Tropomyosin alpha-3 chain antibody; Tropomyosin gamma antibody; Tropomyosin-3 antibody; Tropomyosin-5 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human TPM3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Gene References into Functions
  1. Analysis of the residual, resected tumor identified a chromoplectic TPM3-ALK rearrangement that involved many other known oncogenes and was confirmed by rtPCR. PMID: 27742657
  2. expression levels of tropomyosin 3 (TPM3) were higher in stage III ESCC tissue compared with stage I (P<0.05). The findings of the present study identified twelve proteins, which are closely associated with ESCC invasion and metastasis, apoptosis and cell signal transduction. PMID: 28138712
  3. Dominant mutations in TPM3, encoding alpha-tropomyosinslow, cause a congenital myopathy characterized by generalized muscle weakness. Here, we used a multidisciplinary approach to investigate the mechanism of muscle dysfunction in 12 TPM3-myopathy patients. PMID: 26307083
  4. This work expands the phenotypic spectrum of TPM3-related disease and provides insights into the pathophysiological mechanisms of the actin-tropomyosin complex PMID: 26418456
  5. Western blot showed phosphorylation of ALK, ERK1/2, and STAT3 in cells transfected with TPM3-ALK. Coiled-coil structure of TPM3 contributes to the transforming ability of the TPM3-ALK fusion protein, and longer TPM3 region leads to higher dimer formation. PMID: 25596129
  6. DATA show that tropomyosin 3 protein (TPM3) plays a critical role in the progression of gliomas. PMID: 24913705
  7. study reports on a three-generation family with cap myopathy caused by a novel heterozygous mutation in TPM3 PMID: 24239060
  8. TPM3-R167H mutations decreased cooperative thin filament activation in combination with reductions in the myosin cross-bridge number and force production. PMID: 22798622
  9. TPM3 is an interacting partner of granulin-epithelin precursor and may play an important role in hepatocarcinogenesis. PMID: 22792281
  10. investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TPM3, stomatin-like protein 2, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified. PMID: 22158085
  11. study reports clinico-pathological and electrophysiological features of 2 unrelated cases with heterozygous TPM3 mutation; cases highlight neuromuscular transmission defect in congenital myopathy with fibre type disproportion secondary to TPM3 mutations PMID: 20951040
  12. High TPM3-PDGFRB fusion protein expression is associated with chronic eosinophilic leukemia. PMID: 21072821
  13. variation in the tropomyosin isoform composition of microfilaments provides a mechanism to generate functionally distinct filament populations PMID: 21036167
  14. TPM3 mutations are involved in fiber size disproportion in congenital myotonic dystrophy PMID: 20179953
  15. the clinical, myopathological and muscle MRI findings in a German family with autosomal dominant nemaline myopathy due to a novel pathogenic TPM3 mutation PMID: 20012312
  16. Overexpression of TPM3 activates Snail mediated EMT, which will repress E-cadherin expression and that it confers migration or invasion potentials to HCC cells during hepatocarcinogenesis. PMID: 20356415
  17. Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia. PMID: 20223922
  18. Mutations in TPM3 were identified in 6 out of 13 patients with Congenital fiber type disproportion, as well as in one case of nemaline myopathy. PMID: 19953533
  19. cloned and sequenced a novel nonmuscle tropomyosin (hTM) isoform, TC22, which is strongly associated with colonic neoplasia and carcinoma PMID: 12105844
  20. A mutation converting the stop codon to a serine and a second splicing mutation predicted to prevent inclusion of skeletal muscle exon IX were found associated with nemaline myopathy PMID: 12196661
  21. De novo missense mutation in a constitutively expressed exon of the slow alpha-tropomyosin gene TPM3 associated with an atypical, sporadic case of nemaline myopathy. PMID: 12467750
  22. tropomyosin isoforms regulate neuronal size and shape PMID: 15888546
  23. second pedigree with autosomal dominant nemaline myopathy caused by TPM3 mutation(Arg167His). PMID: 17376686
  24. Mutation of TPM3 is the most common cause of congenital fiber type disproportion reported to date. PMID: 18300303
  25. The mutation reported here is the first deletion to be identified in TPM3, and it is likely to be a founder mutation in the Turkish population. PMID: 18382475
  26. TTC9A acts as a chaperone protein to facilitate the function of tropomyosins (including Tm5NM-1) in stabilizing microfilament and it may play a role in cancer cell invasion and metastasis PMID: 18699990
  27. We report a TPM3 mutation in one of the original cases of cap disease. PMID: 19487656

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Involvement in disease
Nemaline myopathy 1 (NEM1); Myopathy, congenital, with fiber-type disproportion (CFTD); Cap myopathy 1 (CAPM1)
Subcellular Location
Cytoplasm, cytoskeleton.
Protein Families
Tropomyosin family
Database Links

HGNC: 12012

OMIM: 164970

KEGG: hsa:7170

STRING: 9606.ENSP00000357516

UniGene: Hs.535581

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