TPST2 Antibody

Datasheet

Code	CSB-PA024133LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA024133LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA024133LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TPST2 Polyclonal antibody

Uniprot No.

O60704

Target Names

TPST2

Alternative Names

EC 2.8.2.20 antibody; Protein tyrosine sulfotransferase 2 antibody; Protein-tyrosine sulfotransferase 2 antibody; TANGO13B antibody; TPST-2 antibody; Tpst2 antibody; TPST2_HUMAN antibody; Transport and golgi organization 13 homolog B antibody; Tyrosylprotein phosphotransferase 2 antibody; Tyrosylprotein sulfotransferase 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein-tyrosine sulfotransferase 2 protein (26-377AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TPST2 Antibody (Product code: CSB-PA024133LA01HU) is Non-conjugated. For TPST2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA024133LB01HU	TPST2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA024133LC01HU	TPST2 Antibody, FITC conjugated
Biotin	CSB-PA024133LD01HU	TPST2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.

Gene References into Functions

Using a quantum mechanics protocol of alanine scanning, the study identified unequivocally the role of the amino acids involved in the TPST-2 catalytic mechanism. PMID: 26108987
the first crystal structure of the human tyrosylprotein sulfotransferase isoform 2 complexed with a substrate peptide (C4P5Y3) derived from complement C4 and 3'-phosphoadenosine-5'-phosphate at 1.9 A resolution, is reported. PMID: 23481380
The p.R153H variant was found in a family with hereditary pancreatitis; however, it did not segregate with the disease. PMID: 20460947
Shear stress-dependent upregulation of TPST2 in human endothelium is mediated by a tyrosine kinase-dependent pathway PMID: 12056800
Tyrosine sulfation of CCR5 N-terminal peptide follows a discrete pattern and temporal sequence PMID: 12169668
The kinetic parameters of tyrosylprotein sulfotransferase-1 and -2, catalyzing tyrosine sulfation of CCR8 peptides, were determined using liquid chromatography electrospray ionisation mass spectrometry. PMID: 18672380

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Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Protein sulfotransferase family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 12021

OMIM: 603126

KEGG: hsa:8459

STRING: 9606.ENSP00000339813

UniGene: Hs.632768

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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