Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TRIM8 Polyclonal antibody

Uniprot No.

Q9BZR9

Target Names

TRIM8

Alternative Names

AA408830 antibody; BB006755 antibody; GERP antibody; Glioblastoma-expressed RING finger protein antibody; Lioblastoma expressed ring finger protein antibody; Probable E3 ubiquitin-protein ligase TRIM8 antibody; RING finger protein 27 antibody; RNF27 antibody; RP11-47A8.4 antibody; TRIM8 antibody; TRIM8_HUMAN antibody; Tripartite motif containing 8 antibody; Tripartite motif protein TRIM8 antibody; Tripartite motif-containing protein 8 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Probable E3 ubiquitin-protein ligase TRIM8 protein (367-517AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction.

Gene References into Functions

TRIM8 activates STAT3 by suppressing the expression of PIAS3, an inhibitor of STAT3, most likely through E3-mediated ubiquitination and proteasomal degradation. PMID: 28100038
we provided evidence that TRIM8 and its regulators miR-17-5p and miR-106b-5 participate to a feedback loop controlling cell proliferation through the reciprocal modulation of p53, miR-34a and N-MYC. PMID: 28327152
A pathogenic effect of a heterozygous truncating mutation in the tripartite motif containing 8 (TRIM8) gene on the postnatal development of the human brain. PMID: 27346735
Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. PMID: 26077989
These findings provide the first mechanistic link between TRIM8 and the drug resistance of clear cell Renal Cell Carcinoma PMID: 25277184
Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-kappaB pathway. PMID: 23152791
TRIM8 is a p53 direct target gene that induces p53 stabilization and promotes the degradation of MDM2 protein. PMID: 22262183
Tripartite motif 8 (TRIM8) modulates TNFalpha- and IL-1beta-triggered NF-kappaB activation by targeting TAK1 for K63-linked polyubiquitination. PMID: 22084099
TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90beta and consequently regulates transcription of Nanog in embryonic stem cells. PMID: 21689689
These findings indicate that TRIM8 enhances the STAT3-dependent signal pathway by inhibiting the function of PIAS3. PMID: 20516148
interacts with SOCS-1 PMID: 12163497
Gerp transcribes interferon-gamma in epithelial and lymphoid cells and is expressed almost ubiquitously in tissues. PMID: 15345195
Among genes correlated to nodal metastatic progression, we verified in vitro that NM23-H3 reduced cell motility and TRIM8 were a growth suppressor. PMID: 17900511

Hide All

Subcellular Location

Cytoplasm. Nucleus.

Protein Families

TRIM/RBCC family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 15579

OMIM: 606125

KEGG: hsa:81603

STRING: 9606.ENSP00000302120

UniGene: Hs.336810

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Code	CSB-PA871629LD01HU
Size	US$166
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TRIM8 Antibody, Biotin conjugated

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Target Background