TRIM8 Antibody, FITC conjugated

Code CSB-PA871629LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRIM8 Polyclonal antibody
Uniprot No.
Target Names
TRIM8
Alternative Names
AA408830 antibody; BB006755 antibody; GERP antibody; Glioblastoma-expressed RING finger protein antibody; Lioblastoma expressed ring finger protein antibody; Probable E3 ubiquitin-protein ligase TRIM8 antibody; RING finger protein 27 antibody; RNF27 antibody; RP11-47A8.4 antibody; TRIM8 antibody; TRIM8_HUMAN antibody; Tripartite motif containing 8 antibody; Tripartite motif protein TRIM8 antibody; Tripartite motif-containing protein 8 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Probable E3 ubiquitin-protein ligase TRIM8 protein (367-517AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Modulates also STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction.
Gene References into Functions
  1. TRIM8 activates STAT3 by suppressing the expression of PIAS3, an inhibitor of STAT3, most likely through E3-mediated ubiquitination and proteasomal degradation. PMID: 28100038
  2. we provided evidence that TRIM8 and its regulators miR-17-5p and miR-106b-5 participate to a feedback loop controlling cell proliferation through the reciprocal modulation of p53, miR-34a and N-MYC. PMID: 28327152
  3. A pathogenic effect of a heterozygous truncating mutation in the tripartite motif containing 8 (TRIM8) gene on the postnatal development of the human brain. PMID: 27346735
  4. Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients. PMID: 26077989
  5. These findings provide the first mechanistic link between TRIM8 and the drug resistance of clear cell Renal Cell Carcinoma PMID: 25277184
  6. Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-kappaB pathway. PMID: 23152791
  7. TRIM8 is a p53 direct target gene that induces p53 stabilization and promotes the degradation of MDM2 protein. PMID: 22262183
  8. Tripartite motif 8 (TRIM8) modulates TNFalpha- and IL-1beta-triggered NF-kappaB activation by targeting TAK1 for K63-linked polyubiquitination. PMID: 22084099
  9. TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90beta and consequently regulates transcription of Nanog in embryonic stem cells. PMID: 21689689
  10. These findings indicate that TRIM8 enhances the STAT3-dependent signal pathway by inhibiting the function of PIAS3. PMID: 20516148
  11. interacts with SOCS-1 PMID: 12163497
  12. Gerp transcribes interferon-gamma in epithelial and lymphoid cells and is expressed almost ubiquitously in tissues. PMID: 15345195
  13. Among genes correlated to nodal metastatic progression, we verified in vitro that NM23-H3 reduced cell motility and TRIM8 were a growth suppressor. PMID: 17900511

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
TRIM/RBCC family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 15579

OMIM: 606125

KEGG: hsa:81603

STRING: 9606.ENSP00000302120

UniGene: Hs.336810

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