TRIOBP Antibody

1. Results reveal that Tara forms a functional complex with Ndel1 and alters its intracellular distribution. The Ndel1-Tara complex plays a role in regulating actin cytoskeleton organization, which is critical for cell migration. PMID: 27546710
2. Case Reports: novel TRIOBP mutations associated with moderate, stable hereditary hearing impairment. PMID: 28089734
3. Based on whole exome analysis, we identified two TRIOBP pathogenic variants (c.802_805delCAGG, p.Gln268Leufs*610 and c.5014G>T, p.Gly1672*, the first of which was novel) causative of nonsyndromic, peri- to postlingual, moderate-to-severe hearing loss in three siblings from a Polish family. PMID: 29197352
4. TRIOBP-1 aggregation, therefore, appears to occur through one or more specific cellular mechanisms, which therefore have the potential to be of physiological relevance for the biological process underlying the development of chronic mental illness. PMID: 28438837
5. We discovered two genome-wide significant SNPs. The first was novel and near ISG20. The second was in TRIOBP, a gene previously associated with prelingual nonsyndromic hearing loss. Motivated by our TRIOBP results, we also looked at exons in known hearing loss genes, and identified two additional SNPs, rs2877561 in ILDR1 and rs9493672 in EYA4 (at a significance threshold adjusted for number of SNPs in those regions). PMID: 27764096
6. TRIOBP-1 aggregates are implicated for the first time as a biological element of the neuropathology of a subset of chronic mental illness PMID: 25333879
7. High TRIOBP expression is associated with pancreatic cancer. PMID: 25130170
8. TAP68 functions in mediating TRF1-tankyrase 1 localization to the centrosome and in mitotic regulation PMID: 24692559
9. the centrosomal localization of Tara depended on the Thr-457 phosphorylation and the kinase activity of Plk1. PMID: 22820163
10. Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. PMID: 16385457
11. Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. PMID: 16385458
12. All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara. PMID: 18194665

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HGNC: 17009

OMIM: 609761

KEGG: hsa:11078

STRING: 9606.ENSP00000384312

UniGene: Hs.533030