TRPM1 Antibody, HRP conjugated

Datasheet
Code CSB-PA773791LB01HU
Size US$299
Uniprot No. Q7Z4N2
Protocols ELISA Protocol
Immunogen Recombinant Human Transient receptor potential cation channel subfamily M member 1 protein (1-97AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Transient receptor potential cation channel subfamily M member 1 (Long transient receptor potential channel 1) (LTrpC1) (Melastatin-1), TRPM1, LTRPC1 MLSN MLSN1
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names TRPM1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.
Involvement in disease Night blindness, congenital stationary, 1C (CSNB1C)
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM1 sub-subfamily
Tissue Specificity Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented
Database Links

HGNC: 7146

OMIM: 603576

KEGG: hsa:4308

STRING: 9606.ENSP00000380897

UniGene: Hs.155942

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