TRPM1

The TRPM1 gene encodes the transient receptor potential cation channel, subfamily M, member 1 protein, also known as melastatin. This protein functions as a non-selective cation channel, primarily expressed in the retina and melanocytes. TRPM1 is activated by various stimuli, including glutamate and UVB light, and plays a crucial role in the visual pathway and melanin metabolism. It is involved in the signaling pathway of ON bipolar cells, where it mediates the photoresponse. Mutations in TRPM1 are associated with congenital stationary night blindness and melanoma. Research on TRPM1 has led to potential drug targets for treating these conditions.