TTBK2 Antibody

1. Enhanced expression of circ-TTBK2 promoted cell proliferation, migration, and invasion, while inhibited apoptosis in glioma cells. PMID: 28219405
2. TTBK2 down-regulates GluK2 activity by decreasing the receptor protein abundance in the cell membrane via RAB5-dependent endocytosis. PMID: 27607061
3. TTBK2 is a multifunctional kinase involved in important cellular processes and demands augmented efforts in investigating its functions PMID: 25950000
4. TTBK2 phosphorylates KIF2A and antagonizes KIF2A-induced depolymerization at microtubules plus ends for cell migration. PMID: 26323690
5. TTBK2 bound EB1 and Cep164 through its SxIP motifs and a proline-rich motif, respectively. PMID: 25297623
6. data suggest that TTBK2 also acts upstream of Cep164, contributing to the assembly of distal appendages PMID: 24982133
7. Dominant truncating mutations in human TTBK2 cause spinocerebellar ataxia type 11 (SCA11); these mutant proteins do not promote ciliogenesis and inhibit ciliogenesis in wild-type cells. PMID: 23141541
8. TTBK2 is a completely novel regulator of Na(+)-coupled glucose transport. PMID: 22814243
9. findings reveals a major role of PRKX, TTBK2 and RSK4 in triggering Sunitinib resistance formation; data suggest transcriptional regulation of these kinases together with other proteins might play an important role in formation of Sunitinib resistance by affecting transcription factors PMID: 22020623
10. two-basepair deletion (c.1306_1307delGA, p.D435fs448X in exon 12) lead to a premature stop codon in the TTBK2 gene; spinocerebellar ataxia patients had phenotypic of slowly progressive almost pure cerebellar ataxia with normal life expectancy PMID: 20667868
11. Examination the TTBK2 gene in 68 unrelated spinocerebellar ataxia patients displayed the normal elution profile, which denoted that no disease-related mutation was identified. We provided the evidence that SCA11 is a rare form of ataxia in China. PMID: 19768375
12. These data suggest that TTBK2 is important in the tau cascade and in spinocerebellar degeneration. PMID: 18037885
13. that SCA11 is an extremely rare cause for dominantly inherited ataxias (TTBK2) in the German population. PMID: 19533200

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HGNC: 19141

OMIM: 604432

KEGG: hsa:146057

STRING: 9606.ENSP00000267890

UniGene: Hs.646511