TUSC2 Antibody

1. TUSC2P can suppresses the tumor function of esophageal squamous cell carcinoma by regulating TUSC2 expression and may also serve as a prognostic factor for esophageal squamous cell carcinoma patients. PMID: 30219035
2. these findings show that the combination of TUSC2-erlotinib induces additional novel vulnerabilities that can be targeted with Auranofin. PMID: 27845352
3. Data show that TUSC2 is a direct target of miR-584, which is transcriptionally regulated by TWIST1. PMID: 27661106
4. FOXP1, TP53INP1, TNFAIP3, and TUSC2 were identified as miR-19a targets. PMID: 26367773
5. The therapeutic activity of TUSC2 could extend the use of erlotinib to lung cancer patients with wildtype EGFR. PMID: 26053020
6. TUSC2P and TUSC2 3'-UTR expression inhibits cell proliferation, survival, migration, invasion and colony formation, and increases tumor cell death. TUSC2P and TUSC2 3'-UTR bind to miRNAs and arrest their functions, leading to increased TUSC2 translation. PMID: 24394498
7. The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner. PMID: 24146957
8. RNA sequence elements in FUS1 UTRs that regulate FUS1 protein express were identified. PMID: 21645495
9. Absence of tumor suppressor FUS1 protein expression is associated with bone and soft tissue sarcomas. PMID: 21273575
10. Data show that the recombinant FUS1 plasmid has been successfully cloned, which allows highly efficient FUS1 expression in E.coli strain Rosetta (DE3)2 plys. PMID: 17545076
11. The goal of this study was to analyze possible involvement of TUSC2 in malignant pleural mesothelioma. PMID: 19852844
12. Myristoylation is required for Fus1-mediated tumor-suppressing activity and suggest a novel mechanism for the inactivation of tumor suppressors in lung cancer. PMID: 15126327
13. These results suggest that miR-378 enhances cell survival, tumor growth, and angiogenesis through repression of the expression of two tumor suppressors, Sufu and Fus-1. PMID: 18077375
14. FUS1 gene and Fus1 protein abnormalities could be used to develop new strategies for molecular cancer therapy for a significant subset of lung tumors. PMID: 18172250
15. These results suggest that the three miRNAs are negative regulators of Fus1 expression in lung cancers. PMID: 19671678
16. Overexpression of candidate tumor suppressor geneFUS1 isolated from the 3p21.3 homozygous deletionregion leads to G1 arrest and growth inhibition oflung cancer cells. PMID: 11593436

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HGNC: 17034

OMIM: 607052

KEGG: hsa:11334

STRING: 9606.ENSP00000232496

UniGene: Hs.517981