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Code | CSB-PA179850 |
Size | US$299 How to order? |
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Have Questions? | Leave a Message or Start an on-line Chat |
Uniprot No. | P0CG47 | ||||||||
Target Names | UBB | ||||||||
Alternative Names | UBB antibody; UBB_HUMAN antibody; Ubiquitin antibody | ||||||||
Raised in | Rabbit | ||||||||
Species Reactivity | Human,Mouse,Rat | ||||||||
Immunogen | Fusion protein of Human UBB | ||||||||
Immunogen Species | Homo sapiens (Human) | ||||||||
Conjugate | Non-conjugated | ||||||||
Isotype | IgG | ||||||||
Purification Method | Antigen affinity purification | ||||||||
Concentration | It differs from different batches. Please contact us to confirm it. | ||||||||
Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | ||||||||
Form | Liquid | ||||||||
Tested Applications | ELISA,WB,IHC | ||||||||
Recommended Dilution |
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Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
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Troubleshooting and FAQs | Antibody FAQs | ||||||||
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||||
Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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Function |
Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
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Gene References into Functions |
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Subcellular Location | [Ubiquitin]: Cytoplasm. Nucleus. |
Protein Families | Ubiquitin family |
Database Links |
HGNC: 12463 OMIM: 191339 KEGG: hsa:7314 STRING: 9606.ENSP00000304697 UniGene: Hs.356190 |