UBE2L3 Antibody

1. Crystal structure of HHARI and UbcH7 reveals UbcH7 approximately Ub binding RING1 domain of auto-inhibited HHARI. PMID: 28552575
2. Data suggest ordered binding of UBCH7-ubiquitin to E6AP Site 1 (for E6AP-Cys820/ubiquitin thioester formation) and E6AP Site 2 (for subsequent chain elongation); proximal indexation accounts for radially symmetric structure of E6AP, requirement for oligomerization in polyubiquitin chain formation, and mechanistic rationale for Cys820-ubiquitin thioester as platform in chain assembly. (E6AP = ubiquitin-protein ligase E6AP) PMID: 28924046
3. The TCGGC haplotype is associated with an increased risk of Hashimoto Thyroiditis(HT) and UBE2L3 gene is likely to be a susceptibility factor to HT in a Chinese Han population. PMID: 27094594
4. together with UBE2N and UBE2D2, synergistically contribute to Parkin-mediated mitophagy PMID: 24906799
5. The MAP1B-LC1 could interact with the ubiquitin-conjugating E2 enzyme UBE2L3 and that the ubiquitination/degradation mechanism triggered by MAP1B-LC1 could be prevented by inhibiting the ubiquitin-proteasome proteolytic pathway. PMID: 25483588
6. An interaction between LC1 and the ubiquitin-conjugating enzyme UBE2L3. PMID: 24566975
7. UbcH7 has a role in regulating 53BP1 stability and DSB repair PMID: 25422456
8. UBE2L3 polymorphism amplifies NF-kappaB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases. PMID: 25640675
9. Report role of UBE2L3 genetic variants in confering risk of systemic lupus erythematosus in Chinese population. PMID: 24091983
10. Importance of HLA-C and UBE2L3 in the clearance of HBV infection in addition to HLA-DP and HLA-DQ. PMID: 24162738
11. The results suggest that variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBCH7 expression. PMID: 22476155
12. UBE2L3 was found to be a shared susceptibility gene for siffuse cutaneous systemic sclerosis in a Japanese population. PMID: 22294623
13. The interaction between UBE2L3 genotype and autoantibodies upon serum IFN-alpha suggests a biological role for this locus in patients with systemic lupus erythematosus. PMID: 22045845
14. Crystal structures of two bacterial E3s, Salmonella SopA and Escherichia coli NleL, both in complex with human E2 UbcH7, are reported. PMID: 22308380
15. UBCH7 exhibits activity with the RING-in-between-RING (RBR) family of E3s that includes parkin (also known as PARK2) and human homologue of ariadne (HHARI; also known as ARIH1) PMID: 21532592
16. Genetic variations of UBE2L3 and BCL3 are potential new risk genes for Crohn's disease. PMID: 20601676
17. UbcH7 charged with ubiquitin has an affinity for E6-associated protein (E6AP) similar to that of uncharged UbcH7. PMID: 20039703
18. UBE2L3, the c-myc-regulated gene is involved in genotype-C-HBV-related HCC, suggesting that c-myc is related to the hepatocarcinogenic activity of genotype-C HBV. PMID: 16703398
19. identification of the amino acid residues responsible for the HECT-E2 interaction, and for the dynamical properties of the ubiquitin transfer process, may be of relevant interest for pharmacological and therapeutical purposes PMID: 18805400
20. These data suggest a role for UbcH7 targets in the completion of cell cycle S phase and entry into G2. PMID: 18946090

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HGNC: 12488

OMIM: 603721

KEGG: hsa:7332

STRING: 9606.ENSP00000344259

UniGene: Hs.108104