UBE2M Antibody, HRP conjugated

Datasheet

Code	CSB-PA025468OB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) UBE2M Polyclonal antibody

Uniprot No.

P61081

Target Names

UBE2M

Alternative Names

hUbc12 antibody; NEDD8 carrier protein antibody; NEDD8 conjugating enzyme Ubc12 antibody; NEDD8 protein ligase antibody; NEDD8-conjugating enzyme Ubc12 antibody; UBC-RS2 antibody; UBC12 antibody; UBC12_HUMAN antibody; ube2m antibody; ubiquitin carrier protein M antibody; Ubiquitin conjugating enzyme E2 M antibody; Ubiquitin-conjugating enzyme E2 M antibody; ubiquitin-protein ligase M antibody; yeast UBC12 homolog antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Peptide sequence from Human NEDD8-conjugating enzyme Ubc12 protein (11-28AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.

Gene References into Functions

the DCN1-UBC12 interaction is inhibited by DI-591, a high-affinity, cell-permeable small-molecule inhibitor that binds to purified recombinant human DCN1 and DCN2 proteins with K i values of 10-12 nM PMID: 29074978
Furthermore, the authors characterized SENP8/DEN1 as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8-deficient cells. PMID: 28475037
GlyRS preferentially binds and protects Ubc12. PMID: 27348078
Polymorphisms in the UBE2M gene are associated with cetuximab efficacy in colorectal cancer. PMID: 26206335
UBE2M is required to maintain genome integrity by activating multiple Cullin ligases throughout the cell cycle. PMID: 25025768
Distinct preferences of UBC12 and UBE2F peptides for inhibiting different DCNLs, including the oncogenic DCNL1. PMID: 23201271
Our results demonstrate a role for UBE2M in mediating cytotoxicity of gemcitabine in human urothelial carcinoma cells. PMID: 21477582

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Protein Families

Ubiquitin-conjugating enzyme family, UBC12 subfamily

Database Links

HGNC: 12491

OMIM: 603173

KEGG: hsa:9040

STRING: 9606.ENSP00000253023

UniGene: Hs.406068

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Ubiquitin mediated proteolysis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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