UBE4B Antibody

1. miR-1301 functions as a tumor suppressor that inhibits tumor cell migration and invasion in multiple human cancer cells by regulating the UBE4B-p53 pathway. PMID: 28483517
2. UBE4B promotes endogenous phospho-p53(S15) and phospho-p53(S392) degradation in response to gamma irradiation. UBE4B plays an important role in regulating phosphorylated p53 following DNA damage. PMID: 26673821
3. UBE4B overexpression promotes the oncogenic properties of HCC and is correlated with an unfavorable prognosis in HCC patients. PMID: 25557723
4. UBE4B regulates p53 in breast cancer PMID: 24587254
5. We propose a model in which the coordinated action of UBE4B, ESCRT-0, and the deubiquitinating enzyme USP8 enable the endosomal sorting and lysosomal degradation of the EGFR. PMID: 24344129
6. UBE4B-mediated growth factor receptor trafficking may contribute to the poor prognosis of patients who have neuroblastoma tumors with 1p36 deletions. PMID: 22990745
7. The regulated expression of these UFD2a isoforms most likely imparts divergent functions that are important for myogenesis. PMID: 22174917
8. we found somatic mutations of HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B genes in gastric carcinoma and colorectal carcinomas with microsatellite instability PMID: 22124266
9. data indicate that amplification and overexpression of UBE4B represent previously undescribed molecular mechanisms of inactivation of p53 in brain tumors PMID: 21317885
10. determined structures of E4B U box free and bound to UbcH5c and Ubc4 E2s; findings show E4B U box is a monomer stabilized by a network of hydrogen bonds; findings suggest allosteric regulation of UbcH5c and Ubc4 by E4B U box PMID: 20696396
11. A splice site mutation was found in UBE4b. UBE4B expression was diminished in the high-stage/poor-outcome tumors.UBE4B stands out as the strongest candidate NBL tumor suppressor gene in the region at this stage. PMID: 12700669
12. E4B serves as a ubiquitin ligase for FEZ1 and thereby regulates its function but not its degradation PMID: 15466860
13. we have identified a novel domain (the MPAC domain: Mitotically Phosphorylated, Apoptotically Cleaved) present at the N-terminus of Ufd2a, which is regulated both by cleavage during cell death, and by phosphorylation during mitosis. PMID: 16870146
14. Our current study provides an insight onto the regulation of DeltaNp63alpha protein levels in response to cisplatin and also suggests that UFD2a might play an important role in the regulation of cisplatin mediated cell death mediated by p63. PMID: 18418053

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HGNC: 12500

OMIM: 613565

KEGG: hsa:10277

STRING: 9606.ENSP00000343001

UniGene: Hs.593974