Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) UNC5B Polyclonal antibody

Uniprot No.

Q8IZJ1

Target Names

UNC5B

Alternative Names

6330415E02Rik antibody; A630020F16 antibody; D10Bwg0792e antibody; Netrin receptor UNC5B antibody; Netrin receptor UNC5B Precursor antibody; p53 regulated receptor for death and life antibody; p53 regulated receptor for death and life protein 1 antibody; p53-regulated receptor for death and life protein 1 antibody; p53RDL1 antibody; Protein unc-5 homolog 2 antibody; Protein unc-5 homolog B antibody; Protein XUNC 5 antibody; Transmembrane receptor Unc5H2 antibody; Unc 5 homolog 2 antibody; Unc 5 homolog B antibody; Unc 5 netrin receptor B antibody; UNC 5B antibody; Unc5 (C.elegans homolog) b antibody; Unc5b antibody; UNC5B_HUMAN antibody; UNC5H2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Netrin receptor UNC5B protein (404-517AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.

Gene References into Functions

Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation. PMID: 27910960
These findings point to a new important function of UNC5B and provide a potential basis for hASCs-mediated bone regeneration. PMID: 29158083
Our results suggest that UNC5B overexpression inhibits the proliferation and migration of bladder cancer cells by inducing cell cycle arrest at G2/M phase. PMID: 27846823
UNC5B expression is decreased in bladder cancer cells compared to normal bladder cell lines. PMID: 24528886
Data indicate that dysregulation of expression of netrin-1 NTN1 in smooth muscle cell (SMC) and its chemorepulsive receptor UNC5B in macrophages are involved in the development of atherosclerosis and unstable plaques. PMID: 24122613
unc5b expression is greater in adipose tissue of obese versus lean subjects. PMID: 24584118
Higher netrin-1 and lower UNC5B expression in all prostate carcinoma cell lines indicated that netrin-1 and UNC5B could be used to predict metastasis. PMID: 23666553
Low UNC5B expression was an independent risk factor for postoperative recurrence in patients with different stages and grades bladder cancer. PMID: 23055195
UNC5B protein expressed in macrophages in hypoxic regions of atherosclerotic regions in human. PMID: 23599441
UNC5B was downregulated in kidney carcinoma. PMID: 23526078
Reducing Unc5b levels in Sip1 knockout slices and brains rescues cell migration in cortical interneurons. PMID: 23312517
Hypoxia-inducible factor 1 controls the expression of the uncoordinated-5-B receptor, but not of netrin-1, in first trimester human placenta PMID: 22252496
The mRNA expression analysis using tissue samples revealed that UNC5B mRNA was down-expressed in about 20% of CRC patients, and the patients with low-UNC5B-expression tumors showed a significantly higher recurrence rate after curative surgery. PMID: 21922135
Netrin-1 can promote the potential of proliferation and invasion of extravillous trophoblasts in vitro through its receptors neogenin and UNC5B. PMID: 19570425
Robo4 specifically binds to UNC5B, a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors. PMID: 21238923
The recruitment of PP2A to UNC5H2/B allows the activation of DAPk via a PP2A-mediated dephosphorylation and that this mechanism is involved in angiogenesis regulation. PMID: 21172653
Down-regulation of UNC5b gene expression is related to angiogenesis of hepatocellular carcinoma. PMID: 20092749
UNC5B receptor is localized to villous and extravillous cytotrophoblasts proximal to anchoring areas during the first trimester. PMID: 19826074
Modulation of G(ialpha(2)) signaling by the axonal guidance of this protein PMID: 12359238
In this study, we show that Unc5B, a member of the netrin receptor family, interacts with neogenin as a coreceptor for RGMa. PMID: 19273616
Stronger expression of UNC5B and UNC5C receptors in synovial fibroblasts might contribute to the disordered phenotype of rheumatoid arthritis and osteoarthritis. PMID: 19822088