UNC5D Antibody, HRP conjugated

Datasheet
Code CSB-PA740925LB01HU
Size US$299
Uniprot No. Q6UXZ4
Immunogen Recombinant Human Netrin receptor UNC5D protein (90-212AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D), UNC5D, KIAA1777 UNC5H4
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Neuroscience
Target Names UNC5D
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage
Subcellular Location Cell membrane, Single-pass type I membrane protein
Protein Families Unc-5 family
Database Links

HGNC: 18634

OMIM: 616466

KEGG: hsa:137970

STRING: 9606.ENSP00000385143

UniGene: Hs.238889

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