UNC5D Antibody

Code CSB-PA740925LA01HU
Size US$166
Order now
Image
  • Immunofluorescence staining of Hela cells with CSB-PA740925LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) UNC5D Polyclonal antibody
Uniprot No.
Target Names
UNC5D
Alternative Names
UNC5D antibody; KIAA1777 antibody; UNC5H4 antibody; UNQ6012/PRO34692 antibody; Netrin receptor UNC5D antibody; Protein unc-5 homolog 4 antibody; Protein unc-5 homolog D antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Netrin receptor UNC5D protein (90-212AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The UNC5D Antibody (Product code: CSB-PA740925LA01HU) is Non-conjugated. For UNC5D Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA740925LB01HU UNC5D Antibody, HRP conjugated ELISA
FITC CSB-PA740925LC01HU UNC5D Antibody, FITC conjugated
Biotin CSB-PA740925LD01HU UNC5D Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IF
Recommended Dilution
Application Recommended Dilution
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell.
Gene References into Functions
  1. The authors identified a locus on chromosome 8, containing UNC5D, and demonstrated evidence of its genome-wide significance with mental composite scores. Within this locus, the joint effects of two independent single nucleotide polymorphisms had a p-value of 4.38 x 10(-9) for mental composite scores. PMID: 28754176
  2. Unc5D is thus a newly identified transcriptional target of proapoptotic p53 and may also act upstream of p53 to induce p53dependent apoptosis by phosphorylation at ser15. PMID: 24691657
  3. the dependence receptor UNC5H4 may act as a putative tumor suppressor in neuroblastoma. PMID: 24519068
  4. UNC5D is a functional tumor suppressor that is frequently downregulated in RCCs due to promoter hypermethylation and LOH. PMID: 23589179
  5. UNC5D forms a positive feedback loop with p53 and E2F1 to promote NGF dependence-mediated programmed cell death during neuroblastoma regression. PMID: 23778138
  6. UNC5H4 amplifies p53-dependent apoptotic response. PMID: 18402767

Show More

Hide All

Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Unc-5 family
Database Links

HGNC: 18634

OMIM: 616466

KEGG: hsa:137970

STRING: 9606.ENSP00000385143

UniGene: Hs.238889

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*