USO1 Antibody

1. USO1 gene may be a promising target for the therapy of human multiple myeloma and its diagnosis marker. PMID: 26898451
2. USO1 gene has a critical role in human colon cancer: USO1 is involved in cell proliferation and cell migration of colon cancer cells. PMID: 26184508
3. P115 promotes proliferation of gastric cancer cells through an interaction with MIF. PMID: 24379579
4. Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology. PMID: 20209057
5. p115 plays a critical role in mitosis progression, implicating it as the only known golgin to regulate both mitosis and apoptosis PMID: 21536679
6. a conserved tethering function of the Golgi protein p115 CTF which promotes p53-ERK interaction for the amplification of the apoptotic signal. PMID: 21147777
7. Data show that the number of tandem ARM repeats in an ARM fold ranges from 6 to 12. PMID: 20126549
8. Data show that p115 degradation plays a key role in amplifying the apoptotic response independently of Golgi fragmentation. PMID: 12438416
9. p115 acts directly, rather than via a tether, to catalyze trans-SNARE complex formation preceding membrane fusion. PMID: 14736916
10. The results suggest that p115 is involved in vesicular transport between endoplasmic reticulum and the Golgi, along with microtubule networks. PMID: 16256943
11. The interaction between p115 and Cog2 was found to be essential for Golgi ribbon reformation after the disruption of the ribbon by p115 KD or brefeldin A treatment and recovery by re-expression of p115 or drug wash out, respectively. PMID: 17274799
12. Golgi organization depends on mutually interacting domains in betaCOP and p115, suggesting that vesicle tethering at the Golgi involves p115 binding to the COPI coat PMID: 18434597
13. nuclear import of the p115 CTF is required for it to stimulate the apoptotic response and suggest that its mode of action is confined to the nucleus. PMID: 19028683
14. terminal repeat folds into the armadillo superhelical groove and allows homodimeric association with important implications for p115 mediated multiple protein interactions and tethering PMID: 19247479
15. p115 is a critical intermediary component in the regulated secretion of MIF from monocytes/macrophages PMID: 19454686

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HGNC: 30904

OMIM: 603344

KEGG: hsa:8615

UniGene: Hs.744877