USP1 Antibody

Code CSB-PA025695GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
Deubiquitinating enzyme 1 antibody; hUBP antibody; Ubiquitin carboxyl terminal hydrolase 1 antibody; Ubiquitin carboxyl-terminal hydrolase 1 antibody; Ubiquitin specific peptidase 1 antibody; Ubiquitin specific protease 1 antibody; Ubiquitin thioesterase 1 antibody; Ubiquitin thiolesterase 1 antibody; Ubiquitin-specific-processing protease 1 antibody; UBP antibody; UBP1_HUMAN antibody; USP 1 antibody; Usp1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human USP1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
Gene References into Functions
  1. USP1 and capital ER, Cyrilliccapital EN, Cyrillic domain of Bcr-Abl oncoprotein colocalize in a model chronic myeloid leukemia cell system. PMID: 30480413
  2. Our preclinical studies provide the framework for clinical evaluation of USP1 inhibitors, alone or in combination, as a potential novel multiple myeloma therapy. PMID: 28270494
  3. There is evidence that USP1/WDR48 complex promotes cancer stem cell conservation and regulation of DNA damage repair. [REVIEW] PMID: 28302046
  4. These results outline a novel mechanism for the control of TBK1 activity and suggest USP1-UAF1 complex as a potential target for the prevention of viral diseases. PMID: 29138248
  5. USP1 is a key senescence regulator controlling genomic integrity. PMID: 27160904
  6. High USP1 expression is associated with glioma. PMID: 26951930
  7. USP1-UAF1 complex promotes homologous recombination repair via multiple mechanisms: through FANCD2 deubiquitination, as well as by interacting with RAD51AP1. PMID: 27463890
  8. The results suggest that silencing USP1 inhibits cell proliferation and invasion in U2OS cells. Therefore, USP1 may provide a novel therapeutic target for the treatment of osteosarcoma. PMID: 27840911
  9. Translational regulation of the mRNA encoding USP1 is involved in the DNA damage response as a determinant of cisplatin resistance. PMID: 26825230
  10. Ubiquitination-specific proteases 1 (USP1)-mediated protein stabilization promotes glioblastoma (GBM) stem-like cells maintenance and treatment resistance, thereby providing a rationale for USP1 inhibition as a potential therapeutic approach against GBM. PMID: 26032834
  11. analysis of the function and regulation of the USP1-UAF1 complex PMID: 26758085
  12. USP1, p21 and Spartan are translesion DNA synthesis regulators. (Review) PMID: 26002196
  13. No correlation was observed between the protein level of ubiquitin-specific protease 1 (USP1) and ubiquitinated PCNA in BAF180 expressing cells PMID: 26117423
  14. USP1 phosphorylation at S313 is not critical for PCNA deubiquitination, neither for binding to UAF1 in a cellular environment. PMID: 25744535
  15. Coimmunoprecipitation experiments indicated that human papillomavirus type 31 E1 assembles into a ternary complex with UAF1 and any one of these three USPs: USP1, USP12 and USP46. PMID: 24850727
  16. Our findings revealed an intriguing mechanism of regulating USP1 activity that combines phosphorylation of a key serine residue in USP1 and the specific interaction of USP1 with a WD40-repeat protein UAF1 PMID: 23116119
  17. USP1 and UAF1 form a complex in the cytoplasm that subsequently translocates to the nucleus through import mediated by USP1 nuclear localization signals. PMID: 22701671
  18. data identified a novel USP1-PHLPP1-Akt signaling axis, and decreased USP1 level in lung cancer cells may play an important role in lung cancer progress. PMID: 22426999
  19. Studies indicate that USP1 and ELG1 as regulators of PCNA ubiquitylation. PMID: 21640107
  20. Study shows that the deubiquitinating enzyme USP1 promotes ID protein stability and stem cell-like characteristics in osteosarcoma. PMID: 21925315
  21. USP1 levels were kept low in G1 to provide a permissive condition for inducing proliferating cell nuclear antigen (PCNA) monoubiquitination in response to ultraviolet (UV) damage before DNA replication. PMID: 21768287
  22. USP1-regulated and damage-specific DNA-binding protein 1 (DDB1)-dependent mechanisms that are involved in the downregulation of activated CHK1 in human cells. PMID: 21389083
  23. USP1 deubiquitinates FANCD2 protein when cells exit S phase or recommence cycling after a DNA damage insult and may play a critical role in the Fanconi anemia pathway by recycling FANCD2. PMID: 15694335

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Subcellular Location
Nucleus.
Protein Families
Peptidase C19 family
Database Links

HGNC: 12607

OMIM: 603478

KEGG: hsa:7398

STRING: 9606.ENSP00000343526

UniGene: Hs.35086

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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