USP47 Antibody, Biotin conjugated

Code CSB-PA856964LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) USP47 Polyclonal antibody
Uniprot No.
Target Names
USP47
Alternative Names
Deubiquitinating enzyme 47 antibody; TFRP antibody; Trf TATA binding protein related factor proximal homolog antibody; Trf TATA binding protein related factor proximal homolog Drosophila antibody; Ubiquitin carboxyl-terminal hydrolase 47 antibody; Ubiquitin specific peptidase 47 antibody; Ubiquitin specific processing protease 47 antibody; Ubiquitin specific protease 47 antibody; Ubiquitin thioesterase 47 antibody; Ubiquitin thiolesterase 47 antibody; Ubiquitin-specific-processing protease 47 antibody; UBP47_HUMAN antibody; USP47 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ubiquitin carboxyl-terminal hydrolase 47 protein (1-157AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.
Gene References into Functions
  1. these results suggest that USP47 may play distinct roles in ubiquitin-mediated cellular processes via de-ubiquitinating enzymes activity. PMID: 26115687
  2. miR-204-5p acts as a tumor suppressor in gastric cancer through inhibiting USP47 and RAB22A. PMID: 25429829
  3. USP47 is a deubiquitinase that prevents beta-catenin ubiquitination. PMID: 26169834
  4. Data indicate that E-cadherin ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47. PMID: 25253721
  5. The results of this study indicated that USP47 plays a crucial role in the control of axonal growth during neuronal development by antagonizing CHIP-mediated katanin-p60 degradation. PMID: 23904609
  6. USP47 has a role in regulating DNA repair and maintaining genome integrity PMID: 21362556
  7. USP47, a novel beta-Trcp interactor, regulates cell growth and survival, potentially providing a novel target for anticancer therapies. PMID: 19966869

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Subcellular Location
Cytoplasm.
Protein Families
Peptidase C19 family
Tissue Specificity
Expressed in skeletal muscle, heart and testis.
Database Links

HGNC: 20076

OMIM: 614460

KEGG: hsa:55031

STRING: 9606.ENSP00000339957

UniGene: Hs.577256

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