UVRAG Antibody

1. results establish UVRAG as an important effector for melanocytes' response to alpha-MSH signaling as a direct target of MITF and reveal the molecular basis underlying the association between oncogenic BRAF and compromised UV protection in melanoma. PMID: 30061422
2. our study showed that the expression of miR-125b-5p is downregulated in peripheral blood mononuclear cells of systemic lupus erythematosus patients, accompanied by increased UVRAG expression and autophagy activation PMID: 29710477
3. To induce the redistribution of Beclin 1 among its self-associated form or Atg14L/UVRAG-containing complexes enhances both autophagy and endolysosomal trafficking. PMID: 29866835
4. miR-216b enhances the efficacy of vemurafenib and reverses drug resistance by targeting Beclin-1, UVRAG and ATG5 in melanoma. PMID: 28982601
5. Our findings suggest that up-regulation of UVRAG by HDAC1 inhibition potentiates DNA-damage-mediated cell death in colorectal cancer cells PMID: 29277783
6. UVRAG plays an essential role in protecting cells from UV-induced DNA damage by activating the nucleotide excision repair pathway PMID: 27439570
7. UVRAG is a regulator of CRL4(DDB2)-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition. PMID: 27203177
8. Under-expression of UVRAG is associated with colorectal cancer. PMID: 26717041
9. UVRAG frameshift is expressed as a truncated protein in colorectal cancer with microsatellite instability and promotes tumorigenesis. UVRAG(FS) expression renders cells more sensitive to standard chemotherapy regimen due to a DNA repair defect. PMID: 26234763
10. HCV, by differentially inducing the expression of Rubicon and UVRAG, temporally regulated the autophagic flux to enhance its replication. PMID: 25807108
11. tubulation requires mTOR activity, and we identified two direct mTOR phosphorylation sites on UVRAG (S550 and S571) that activate VPS34. PMID: 26139536
12. Beclin 1 and UVRAG confer protection against radiation-induced DNA DNA double strand breaks and may maintain centrosome stability in established tumor cells. PMID: 24956373
13. Dephosphorylation of UVRAG facilitates the lysosomal degradation of epidermal growth factor receptor (EGFR), reduces EGFR signaling, and suppresses cancer cell proliferation and tumor growth. PMID: 25533187
14. The reports that Grb2, when in excess, interacts with ultraviolet radiation resistance-associated gene protein (UVRAG) under excess conditions of AICD-Grb2 or Grb2. PMID: 24882360
15. UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. PMID: 24550300
16. Akt1 may inhibit autophagy by decreasing UVRAG expression, which also sensitizes cancer cells to UV irradiation. PMID: 23200933
17. in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 interacts with the class III PI3K Vps34 in a complex with Beclin-1 and UVRAG PMID: 22493499
18. UVRAG promotes DNA double-strand-break repair by directly binding and activating DNA-PK in nonhomologous end joining. Disruption of UVRAG increases genetic instability and sensitivity of cells to irradiation. PMID: 22542840
19. analysis of how the Beclin1 coiled-coil domain interface regulates homodimer and heterodimer formation with Atg14L and UVRAG PMID: 22314358
20. UVRAG has cytoprotective functions in the cytosol that control the localization of Bax in tumor cells exposed to apoptotic stimuli PMID: 21606679
21. UVRAG has an essential role in the intrinsic mitochondrial pathway of apoptosis by regulating the localization of Bax. PMID: 21597469
22. Data indicate that mechanisms other than autophagy contribute to the tumorigenicity of microsatellite unstable colon carcinomas with monoallelic UVRAG mutation. PMID: 20724836
23. A specific sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates both receptor degradation and cytokinesis, whereas ATG14L, a PI3K-III subunit involved in autophagy, is not required. PMID: 20643123
24. There is an association of UVRAG polymorphisms with susceptibility to non-segmental vitiligo in a Korean sample. PMID: 20163458
25. UVRAG: a new player in autophagy and tumor cell growth. PMID: 17106237
26. Frameshift mutations in the polyadenine tract in UVRAG gene are present in gastric carcinomas. PMID: 18495205
27. Data suggest that a Beclin1-binding autophagic tumour suppressor, UVRAG, interacts with the class C Vps complex, a key component of the endosomal fusion machinery. PMID: 18552835
28. Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1 PMID: 18641390
29. These results suggest that mammalian cells have at least two distinct class III PI3-kinase complexes, and that beclin 1 interacts distinctly with mammalian Atg14 and UVRAG in two of these complexes. PMID: 18843052

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HGNC: 12640

OMIM: 602493

KEGG: hsa:7405

STRING: 9606.ENSP00000348455

UniGene: Hs.202470