UXS1 Antibody, HRP conjugated

Code CSB-PA822754LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) UXS1 Polyclonal antibody
Uniprot No.
Target Names
UXS1
Alternative Names
UXS1 antibody; UNQ2538/PRO6079 antibody; UDP-glucuronic acid decarboxylase 1 antibody; EC 4.1.1.35 antibody; UDP-glucuronate decarboxylase 1 antibody; UGD antibody; UXS-1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human UDP-glucuronic acid decarboxylase 1 protein (201-420AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
Gene References into Functions
  1. The persistence of a latent hexamer-building interface in the human enzyme suggests that the ancestral UXS may have been a hexamer. PMID: 25521717
  2. hUXS forms a tetramer in solution that is important for activity. The higher activity of the tetramer coupled with the relative instability of the dimeric complex suggests that an association-dissociation mechanism may regulate hUXS activity. PMID: 23656592
  3. UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization. PMID: 11877387
  4. Complementation was achieved by expression of a cytoplasmic variant of UDP-xylose Synthase, which proves the existence of a functional Golgi UDP-xylose transporter[UDP-xylose Synthase] PMID: 19028698
Subcellular Location
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Protein Families
NAD(P)-dependent epimerase/dehydratase family, UDP-glucuronic acid decarboxylase subfamily
Database Links

HGNC: 17729

OMIM: 609749

KEGG: hsa:80146

STRING: 9606.ENSP00000387019

UniGene: Hs.469561

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