WDR83 Antibody, Biotin conjugated

Datasheet
Code CSB-PA863110LD01HU
Size US$299
Uniprot No. Q9BRX9
Protocols ELISA Protocol
Immunogen Recombinant Human WD repeat domain-containing protein 83 protein (64-315AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1), WDR83, MORG1
Immunogen Species Homo sapiens (Human)
Research Area Cardiovascular
Target Names WDR83
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.
Subcellular Location Cytoplasm, Nucleus
Protein Families WD repeat MORG1 family
Database Links

HGNC: 32672

KEGG: hsa:84292

STRING: 9606.ENSP00000242796

UniGene: Hs.657204

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