X Antibody, FITC conjugated

Code CSB-PA323774LC01WAW
Size US$166
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Product Details

Full Product Name
Rabbit anti-Woodchuck hepatitis B virus (isolate 8) (WHV) X Polyclonal antibody
Uniprot No.
Target Names
X
Alternative Names
X antibody; Protein X antibody; HBx antibody; Peptide X antibody; pX antibody
Raised in
Rabbit
Species Reactivity
Woodchuck hepatitis B virus
Immunogen
Recombinant Woodchuck hepatitis B virus Protein X protein (1-141AA)
Immunogen Species
Woodchuck hepatitis B virus (isolate 8) (WHV)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
Subcellular Location
Host cytoplasm. Host nucleus. Host mitochondrion.
Protein Families
Orthohepadnavirus protein X family
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