YKT6 Antibody

Datasheet

Code	CSB-PA026265LA01HU
Size	US$166
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Image	Western blot All lanes: YKT6 antibody at 12µg/ml + A549 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 23, 19 kDa Observed band size: 23 kDa Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA026265LA01HU at dilution of 1:100
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) YKT6 Polyclonal antibody

Uniprot No.

O15498

Target Names

YKT6

Alternative Names

R SNARE antibody; SNARE protein Ykt6 antibody; Synaptobrevin homolog YKT6 antibody; YKT 6 antibody; YKT6 antibody; YKT6 S. cerevisiae homolog of antibody; YKT6 v SNARE homolog antibody; YKT6 v SNARE protein antibody; YKT6_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Synaptobrevin homolog YKT6 protein (10-195AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The YKT6 Antibody (Product code: CSB-PA026265LA01HU) is Non-conjugated. For YKT6 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA026265LB01HU	YKT6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA026265LC01HU	YKT6 Antibody, FITC conjugated
Biotin	CSB-PA026265LD01HU	YKT6 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The production process of the YKT6 polyclonal antibody typically involves injecting the rabbit with the recombinant human synaptobrevin homolog YKT6 protein (10-195aa), collecting its serum, and isolating and purifying the antibody through protein G affinity chromatography.

The YKT6 polyclonal antibody is only reactive with the YKT6 protein from human samples. This antibody contains few impurities, claiming up to 95% purity. It has been tested in ELISA, WB, and IHC. It is commonly used as a tool to detect, quantify, and localize the YKT6 protein in various tissues and cell types.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

Gene References into Functions

YKT6 is a key molecule in the regulation of exosome release in lung cancer cells and is in turn precisely regulated by miR-134 and miR-135b. Moreover, YKT6 levels impact prognosis of resected Non small cell lung cancer patients. PMID: 27285987
abnormalities in the SNARE complex could represent a molecular substrate for abnormalities of neural connectivity in severe mental disorders PMID: 11884350
Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport. PMID: 12388752
N-ethylmaleimide-sensitive factor-dependent SNARE-priming complex disassembly is required for efficient exocytosis from mast cells. PMID: 14607937
mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel. PMID: 16821082

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Subcellular Location

Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes.

Protein Families

Synaptobrevin family

Database Links

HGNC: 16959

OMIM: 606209

KEGG: hsa:10652

STRING: 9606.ENSP00000223369

UniGene: Hs.520794

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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