ZEB1 Antibody, FITC conjugated

Code CSB-PA026424LC01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ZEB1 Polyclonal antibody
Uniprot No. P37275
Target Names ZEB1
Alternative Names AREB 6 antibody; AREB6 antibody; BZP antibody; Delta crystallin enhancer binding factor 1 antibody; DELTA EF1 antibody; FECD6 antibody; MGC133261 antibody; Negative regulator of IL 2 antibody; Negative regulator of IL2 antibody; NIL 2 A antibody; NIL 2 A zinc finger protein antibody; NIL 2A antibody; NIL-2-A zinc finger protein antibody; NIL2A antibody; Posterior polymorphous corneal dystrophy 3 antibody; PPCD3 antibody; Represses interleukin 2 expression antibody; TCF 8 antibody; TCF-8 antibody; TCF8 antibody; Transcription factor 8 (represses interleukin 2 expression) antibody; Transcription factor 8 antibody; ZEB 1 antibody; ZEB antibody; ZEB1 antibody; ZEB1_HUMAN antibody; ZFHEP antibody; ZFHX 1A antibody; ZFHX1A antibody; Zinc finger E box binding homeobox 1 antibody; Zinc finger E-box-binding homeobox 1 antibody; Zinc finger homeodomain enhancer binding protein antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Zinc finger E-box-binding homeobox 1 protein (491-676AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Gene References into Functions
  1. These results suggested that EPN3 enhances the migration and invasion of glioblastoma cells by activating the transcription factors Slug, Twist and ZEB1, but not Snail 1 or ZEB2, to induce EMT in glioma cells; EPN3 involvement in the Notch and WNT/betacatenin signaling pathways may contribute to this process. PMID: 30226603
  2. The results demonstrated that ZEB1 was a direct target of miR-200c, and overexpression of miR-200c inhibited the expression of ZEB1 and alpha-SMA. These findings suggest that downregulation of miR-200c in oral submucous fibrosis (OSF) may be involved in the pathogenesis of areca nut-associated OSF through regulation of ZEB1. PMID: 29958727
  3. The present study provides the first evidence that UCA1 promotes glioma metastasis through the miR-204-5p/ZEB1 axis, contributing to the understanding of the pathogenesis of glioma. PMID: 30107990
  4. High ZEB1 expression is associated with Gastric Cancer. PMID: 29295724
  5. Results found that the expression of miR-431 was increased in preeclampsia (PE) patients, whereas, the expression of ZEB1 was decreased. Furthermore, miR-431 was shown to inhibit the migration and invasion of trophoblastic cells by targeting ZEB1, which might give rise to the onset of PE. PMID: 30315928
  6. Zeb1 role in the metastatic dissemination, cancer stem cells and neoplasm resistance to treatment. [review] PMID: 29254997
  7. ultrasound (US) irradiation could reverse Multidrug resistance (MDR) phenotype by activating reactive oxygen species-ZEB1-miR200c/34a-P-gp signal pathway. Our findings offer a new and promising strategy for sensitizing cells to combat MDR and to improve the therapeutic index of chemotherapy PMID: 30231924
  8. Arf6 appears to be necessary for both RhoA- and Rac1-driven cancer invasion PMID: 27754741
  9. High ZEB1 mRNA Stability is associated with Epithelial-Mesenchymal Transition in Breast Cancer. PMID: 29187406
  10. Knockdown of HuR significantly increases the apoptosis of respiratory epithelial cells and down-regulates ZEB-1 expression. PMID: 29866111
  11. Rescue experiments demonstrated that overexpression of ZEB1 attenuated the inhibitory effects of miR574 on the proliferation and invasion of glioblastoma multiforme (GBM)cells. Overall, the results of the present study highlighted the potential tumour inhibitory roles of miR574 in GBM, thereby indicating that miR574 may be a novel and efficient therapeutic target for the treatment of patients with GBM. PMID: 29901177
  12. Data show a direct binding between TP73-AS1, miR-200a and ZEB1. TP73-AS1 promoted ZEB1 expression via competing with its 3'UTR for miR-200a binding. ZEB1 binds the promoter region of TP73-AS1 activating its expression. TP73-AS1 and ZEB1 expression was increased, whereas miR-200a expression was low in breast cancer (BC). These regulating loop TP73-AS1/miR-200a/ZEB1 in BC promotes cancer cell invasion and migration. PMID: 28857253
  13. correlation between the KLF5 and ZEB1 transcription levels in the pancreatic tumor tissues PMID: 30168064
  14. Knockdown of ZEB1 markedly inhibited the expression of vimentin in MDAMB231 cells and markedly increased the expression of Ecadherin. It was suggested that ZEB1 shRNA may have inhibited the epithelialmesenchymal transition (EMT). PMID: 29512767
  15. These results support a previously unrecognized genetic cell context-dependent role for ZEB1. PMID: 27456471
  16. The percentages of ZEB1 high expression and ZEB2 high expression were 31.9% (29/91) and 41.9% (36/91), respectively. High expression of ZEB2 was significantly associated with lower survival rate of GBM patients (P=0.001). PMID: 29476046
  17. ZEB1 play a crucial role in KDM5A induced function. PMID: 29324315
  18. Zinc finger E-box binding homeobox factor 1 (ZEB1) was indicated to be a direct target of miR-128-3p. PMID: 29329360
  19. ZEB1 is a key regulator of the tumor regulatory function of miR-205 in glioblastoma. PMID: 29345288
  20. miRNA-186-5p affects the proliferation, metastasis and EMT process of colorectal cancer cell by inhibition of ZEB1. Hence, it may serve as a promising therapeutic target for colorectal cancer PMID: 29325758
  21. Three SNPs were associated with survival: rs2526614 (TWIST1) (genotype CA + AA, adjusted HR=0.58, 95%CI=0.37-0.93), rs6953766 (TWIST1) (genotype GG, crude HR=2.02, 95%CI=1.06-3.82, adjusted HR=2.14, 95%CI=1.07-4.25), and rs431073 (ZEB1) (genotype AC + CC, crude HR=1.62, 95%CI=1.01-2.59, adjusted HR=1.96, 95%CI=1.18-3.25). PMID: 29970507
  22. PIK3R3 could promote the metastasis of Pancreatic Cancer by facilitating ZEB1 induced Epithelial-Mesenchymal Transition. PMID: 29719293
  23. miR211 may act as a tumor suppressor in cervical cancer by directly targeting ZEB1. PMID: 29115509
  24. Inhibition of ZEB1 promoted prostate cancer apoptosis, restrained proliferation, and suppressed invasion through down-regulating ERK1/2 signaling pathway. PMID: 29028100
  25. These findings implicate ZEB1 as a stem cell regulator in glioma via LIF repression which when deleted leads to increased stemness, tumorigenicity and shortened patient survival. PMID: 28246407
  26. Results showed that ZEB1 was a target gene of miR-127, and miR-127 overexpression-induced impairments in cell growth and metastasis were attenuated when ZEB1 was overexpressed. PMID: 28636101
  27. miR454 under expression may be involved in gastric cancer initiation and progression, by promoting proliferation, migration and invasion by directly targeting ZEB1. PMID: 29039488
  28. The expression of ZEB1 is positively regulated by HOTAIR but negatively miR-23b in hepatocellular carcinoma (HCC) cells. PMID: 29778425
  29. HIF-1alpha/HOTTIP/miR-101/ZEB1 axis plays essential role in hypoxia-induced epithelial-mesenchymal transition and metastasis of glioma. PMID: 28886531
  30. CXCR4 promoter analysis revealed zinc finger E-box binding homeobox 1 (ZEB1) binding sites. Upon DOXO treatment, ZEB1 binding decreased and RNA-polymerase-II increased, suggesting a DOXO-mediated transcriptional increase in CXCR4. PMID: 28837147
  31. The expression level of ZEB1 in bladder cancer samples was significantly more than in healthy adjacent tissue samples and there was a relationship between its over expression and tumor size. PMID: 28261684
  32. These findings provide insight into the role of ZEB1 in the progression of cancer, mediated by inflammatory cytokines, along with the initiation of epithelial-mesenchymal transition. PMID: 28618162
  33. The authors observe that IRF1 expression is mediated by ZEB1 de-repression, and the study demonstrates how airway remodelling/fibrosis is associated with a defective mucosal antiviral response through ZEB1-initiated epigenetic silencing in respiratory virus infection. PMID: 28581456
  34. the present study demonstrated that miR199b was downregulated in NSCLC and acted as a tumor suppressor by targeting ZEB1. PMID: 28849018
  35. miR-643 is a potent tumor suppressor in osteosarcoma. miR-643 directly targeted ZEB1 to induce tumor suppression. Lower expression levels of miR-643 or higher expression levels of ZEB1 were predictors of poor prognosis. PMID: 28849077
  36. silica-stimulated macrophages secreted TGF-beta1 to induce lncRNA-ATB in epithelia cells, promoting epithelial-mesenchymal transition by binding with miR-200c and releasing ZEB1 PMID: 29113749
  37. Results revealed that novel crosstalk between KLF4 and ZEB1 regulated gemcitabine resistance in PDAC. PMID: 28849150
  38. Studied role of lncRNA ZEB1 antisense 1 in prostate cancer epigenetic processes and ZEB1 expression. PMID: 28830551
  39. The present study identified three DDR-associated genes as ZEB1 downstream targets, and demonstrated that their suppression by ZEB1 contributes to ZEB1-mediated chemoresistance. PMID: 28791382
  40. These findings indicated that the down-regulation of PPP3CC by ZEB1 resulted in activation of NF-kappaB is a critical oncogenic event in gliomas. PMID: 29294030
  41. these results demonstrated that miR130a functioned as a tumor suppressor in osteosarcoma, partially via targeting ZEB1. PMID: 28714003
  42. HSV-1 selectively stimulates expression of the miR-183 cluster by ICP0-mediated degradation of ZEB transcriptional repressors. PMID: 28783105
  43. The present study validated the prognostic value and clinicopathological association of ZEB1 and ZEB2 in digestive cancers, especially in gastric cancer. PMID: 28416756
  44. High levels of ZEB1 is associated with metastasis in triple-negative breast cancer. PMID: 28583190
  45. our results suggest that the ZEB1/NNMT signaling axis induces phenotypic and metabolic plasticity, as well as mesenchymal gene expression in ovarian cancer cells upon chronic glucose deprivation PMID: 28412735
  46. Knock-down of ZEB1 expression by RNA interference can decease lncRNA HOTAIR expression and restrain cell proliferation, invasion and migration in gastric cancer BGC823 cells. PMID: 28871949
  47. High ZEB1 expression is associated with breast cancer progression. PMID: 27036021
  48. SNHG1 might play an oncogenic role in SCC through ZEB1 signaling pathway by inhibiting TAp63. PMID: 28415044
  49. some tumor suppressor functions of Beclin 1 were mediated through posttranscriptional regulation of ZEB1 via AUF1 in thyroid cancers. PMID: 27683118
  50. This is the first study that relates concurrent expression of Tubbeta3, ZEB1, and beta-catenin to abnormal epithelial and myofibroblast differentiation in idiopathic pulmonary fibrosis, providing indirect but robust evidence of miR-200 deregulation and epithelial to mesenchymal transition activation in idiopathic pulmonary fibrosis. PMID: 27586205

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Involvement in disease Corneal dystrophy, posterior polymorphous, 3 (PPCD3); Corneal dystrophy, Fuchs endothelial, 6 (FECD6)
Subcellular Location Nucleus.
Protein Families Delta-EF1/ZFH-1 C2H2-type zinc-finger family
Tissue Specificity Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skelet
Database Links

HGNC: 11642

OMIM: 189909

KEGG: hsa:6935

STRING: 9606.ENSP00000354487

UniGene: Hs.124503

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