ZFYVE16 Antibody

Datasheet

Code	CSB-PA800100ESR2HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA800100ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA800100ESR2HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA800100ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ZFYVE16 Polyclonal antibody

Uniprot No.

Q7Z3T8

Target Names

ZFYVE16

Alternative Names

AI035632 antibody; B130024H06Rik antibody; B130031L15 antibody; DKFZp686E13162 antibody; Endofin antibody; Endosomal associated FYVE domain protein antibody; Endosome associated FYVE domain protein antibody; Endosome-associated FYVE domain protein antibody; KIAA0305 antibody; KIAA0305; antibody; mKIAA0305 antibody; OTTMUSP00000029589 antibody; RGD1564784 antibody; ZFY16_HUMAN antibody; ZFYVE16 antibody; Zinc finger FYVE domain containing protein 16 antibody; Zinc finger FYVE domain-containing protein 16 antibody; Zinc finger; FYVE domain containing 16 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Zinc finger FYVE domain-containing protein 16 protein (1-280AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.

Gene References into Functions

Two SNPs located near the ZFYVE16 gene on chromosome 5 may have played a role in the early, multicompartment sacrocolpopexy failure. PMID: 26944198
Disruption of proper localization to the endosomes and the Y515 phosphorylation of Endofin enhanced MAPK activation suggesting that Endofin negatively modulates EGFR signaling following receptor endocytosis. PMID: 19887107
marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin or its carboxyl-terminal fragment PMID: 14613930
The key mode of action of Trx-SARA was to reduce the level of Smad2 and Smad3 in complex with Smad4 after TGF-beta1 stimulation. PMID: 16775010
Facilitates TGF-beta signaling as a scaffold protein to promote the R-Smad-Smad4 complex formation by bringing Smad4 to the proximity of the receptor complex. PMID: 17272273
our study is the first to identify and validate Endofin, DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine signaling network PMID: 17570516

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Subcellular Location

Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P).

Tissue Specificity

Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes.

Database Links

HGNC: 20756

OMIM: 608880

KEGG: hsa:9765

STRING: 9606.ENSP00000337159

UniGene: Hs.482660

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

TGF-beta signaling pathway Endocytosis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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