fgf3 Antibody, Biotin conjugated

Code CSB-PA008630LD01DIL
Size US$166
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) fgf3 Polyclonal antibody
Uniprot No.
Target Names
fgf3
Alternative Names
fgf3 antibody; fgf-3Fibroblast growth factor 3 antibody; FGF-3 antibody; Heparin-binding growth factor 3 antibody; HBGF-3 antibody
Raised in
Rabbit
Species Reactivity
Zebrafish
Immunogen
Recombinant Zebrafish Fibroblast growth factor 3 protein (19-256AA)
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation.
Gene References into Functions
  1. Pharmacological inhibition of FGF signaling or a mutation in the fgf3 gene can compensate the gain of caudal hypothalamic dopaminergic neurons in cnot8m1061 mutants, indicating a role for Fgf3 in control of development of this dopaminergic population PMID: 25478689
  2. Fgf10b participates in a late phase of otic induction and, in combination with fgf3, is especially critical for epibranchial induction. PMID: 24677486
  3. Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish. PMID: 24358375
  4. Myogenic factor (Myf)5 modulates craniofacial cartilage development through the fgf3 signaling pathway. PMID: 23992145
  5. Data indicate that foxi1 is expressed in branchial arch ectoderm and endoderm, and morpholino knock-down of foxi1 causes apoptosis of neural crest in the branchial arches, which is rescued by fgf3. PMID: 24650709
  6. Fgf10 and Fgf3 secreted from the forming neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons. PMID: 23404108
  7. In lia(-/-) (fgf3(-/-)) mutants, anterior otic character is reduced, but not lost altogether. PMID: 21831919
  8. Requirement for endoderm and FGF3 in ventral head skeleton formation PMID: 12223404
  9. Results show that fibroblast growth factor 3 signaling from the ventral diencephalon is required to induce the expression of lim3, pit1 and other pituitary-specific genes in the underlying adenohypophyseal progenitor cells. PMID: 15229178
  10. Results suggest that Fgf3 is a major endodermal determinant required for epibranchial placode neurogenesis. PMID: 16077091
  11. fgf3 can act as otic inducers PMID: 17239227
  12. The FGF3 signal delineates the melanotrope and corticotrope lineage boundary, contributing to establishment of the pituitary pars distalis and pars intermedia. PMID: 18514643
  13. rosettes form cyclically from a progenitor pool at the leading zone of the posterior lateral line primordium as neuromasts are deposited from trailing region; fgf3/10 signals localized to leading zone required for rosette formation & primordium migration PMID: 18583612
  14. morphogenetic tissue rearrangements during eye evagination result in progenitor cells in the nasal half of the retina primordium being brought into proximity to the sources of three fibroblast growth factors, Fgf8/3/24, outside the eye. PMID: 19823566

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Subcellular Location
Secreted.
Protein Families
Heparin-binding growth factors family
Database Links
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