gag Antibody

Datasheet

Code	CSB-PA315187XA11ASN
Size	US$166
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Image	Western Blot Positive WB detected in: recombinant protein All lanes: gag Antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 36 kDa Observed band size: 36 kDa
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Target Background

Product Details

Uniprot No.

P0C776

Target Names

gag

Alternative Names

Gag polyprotein [Cleaved into: Matrix protein p19, p2A, p2B, p10, Capsid protein p27, alternate cleaved 1, Capsid protein p27, alternate cleaved 2, Spacer peptide (SP) (p3), Nucleocapsid protein p12, Protease p15 (EC 3.4.23.-)], gag

Species Reactivity

Avian leukosis virus RSA

Immunogen

Recombinant Avian leukosis virus RSA gag protein (489-577aa)

Immunogen Species

Avian leukosis virus RSA (RSV-SRA) (Rous sarcoma virus (strain Schmidt-Ruppin A))

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

To produce the gag polyclonal antibody, a rabbit is immunized with recombinant Avian leukosis virus RSA gag protein (amino acids 489-577), resulting in the production of antibodies targeting this antigen. A booster antigen injection enhances antibody production, and serum containing gag polyclonal antibodies is collected and purified through affinity chromatography. The gag antibody's specific recognition of Avian leukosis virus RSA gag protein has been confirmed through ELISA and WB assays.

The Avian Leukosis Virus (ALV) RSA gag protein plays a crucial role in the life cycle of the virus, including capsid formation, viral RNA packaging, facilitation of budding and release of new virus particles, and assembly of virus-like particles.

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Target Background

Function

The p10 domain folds back and interacts with the capsid protein domain during Gag polyprotein assembly in the immature particle (before the maturation cleavage thatz splits the 2 domains).; Capsid protein p27: Self-associates to form the irregular polyhedron core composed of hexamers and pentamers, that encapsulates the genomic RNA-nucleocapsid complex. Assembles as a tube in vitro.; Binds strongly to viral nucleic acids and promote their aggregation. Also destabilizes the nucleic acids duplexes via highly structured zinc-binding motifs.; Plays a role in the oligomerization of the Gag polyprotein and in the stabilization of the immature particle. Essential layering element during tube assembly.; Aspartyl protease that mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell.

Subcellular Location

[Matrix protein p19]: Virion.; [Capsid protein p27, alternate cleaved 1]: Virion.; [Capsid protein p27, alternate cleaved 2]: Virion.; [Nucleocapsid protein p12]: Virion.; [Gag polyprotein]: Host nucleus, host nucleolus. Host nucleus, host nucleoplasm.

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