vacA Antibody, Biotin conjugated

Code CSB-PA14379D0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) vacA Polyclonal antibody
Uniprot No.
Target Names
vacA
Alternative Names
vacA antibody; HP_0887 antibody; Vacuolating cytotoxin autotransporter [Cleaved into: Vacuolating cytotoxin; Vacuolating cytotoxin translocator] antibody
Raised in
Rabbit
Species Reactivity
Helicobacter pylori
Immunogen
Recombinant Helicobacter pylori Vacuolating cytotoxin autotransporter protein (37-245AA)
Immunogen Species
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Induces vacuolation of eukaryotic cells. Causes ulceration and gastric lesions.
Gene References into Functions
  1. Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway. PMID: 29238039
  2. The results indicate that cortactin is involved in the regulation of apoptosis induced by VacA in gastric cells. PMID: 26289258
  3. Genotype testing of vacA s- and m- region will be useful in screening susceptible individuals for duodenal ulcer development. PMID: 25063579
  4. These results suggested that cagA and vacA gene expression is upregulated in Helicobacter pylori, especially by host cell contact, and Fur has a role in the upregulation. PMID: 24020886
Subcellular Location
[Vacuolating cytotoxin autotransporter]: Periplasm.; [Vacuolating cytotoxin]: Secreted. Cell surface.; [Vacuolating cytotoxin translocator]: Cell outer membrane; Multi-pass membrane protein.
Database Links

KEGG: hpy:HP0887

STRING: 85962.HP0887

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