Recombinant Bovine Calpain-1 catalytic subunit (CAPN1), partial

1. Most heifer reproductive traits were not significantly affected by CAST and CAPN1 markers that are widely used to improve beef tenderness by selection and breeders should not be concerned with how these markers affect reproduction and other heifer traits with the possible exception of CAPN1 effects on calving date. PMID: 29448132
2. study is the first report on genetic variant g.-1256 A>C in the promoter region of CAPN1 gene association with the semen quality of Chinese Holstein bulls by influencing its expression PMID: 27107033
3. These results suggest an important role of genetics in meat color variation for cattle raised under the tropic conditions. PMID: 26946475
4. This work is supportive of the importance of CAPN1 and CAST for mean tenderness in beef. PMID: 25414103
5. Suppression of CANP1 resulted in the activation of caspase and heat-shock-protein systems which might in turn regulate apoptosis through the caspase-dependent cell death pathway. [CANP1] PMID: 23943438
6. bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1/CAST4 complex structures PMID: 25215589
7. This work confirms the importance of CAPN1 and CAST for tenderness in beef, provides a new effect of CAST on beef tenderness, and questions the utility of GHR as a selection marker for beef quality. PMID: 24398843
8. It was found that the marker c.3379G > A in the CAPN1 gene influences the Ca content in the meat of this Nelore population, with the rare genotype associated with less Ca content. PMID: 23995697
9. m- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores. PMID: 23549461
10. Association of polymorphisms in calpain 1, (mu/I) large subunit, calpastatin, and cathepsin D genes with meat quality traits in double-muscled Piemontese cattle. PMID: 22548449
11. Relationships of the calpain system with meat tenderness and carcass traits were examined for 94 purebred Angus bulls. PMID: 21127989
12. The association of polymorphisms in calpastatin and mu-calpain genes with meat tenderness in 3 French beef breeds is reported. PMID: 21178177
13. A new insertion/deletion (InDel) polymorphism, consisting of a change of seven nucleotides for only one nucleotide (TCTGGGT --> C) within intron 17 of the CAPN1 gene, is reported. PMID: 20838904
14. mu-calpain (CAPN1S) has a role in the proteolysis process and the meat tenderness of young cattle PMID: 20563650
15. CAPN1 4751 affected all meat traits and CAPN1 316 showed association with tenderness and color. PMID: 20709460
16. The mu-calpain gene marker improved beef tenderness without affecting other objective meat quality traits in heterozygous cattle compared with homozygotes for the unfavorable allele. PMID: 20495132
17. The present study indicated that calpain-system gene markers are suitable for use in marker-assisted selection to improve meat tenderness in Brahman cattle without negative effects on other production and carcass characteristics. PMID: 20525933
18. Single-nucleotide polymorphisms (SNPs) in the calpain (CAPN) and calpastatin (CAST) genes, described from Bos primigenius taurus, were examined to see if they were polymorphic in Nellore cattle. PMID: 20662159
19. Reduced eNOS protein levels were accompanied by an increase in intracellular Ca(2+), augmented production of reactive oxygen species (ROS) and induction of Ca(2+)-dependent calpain activity. PMID: 18624772
20. investigation of calpain 1 binding with alpha-actinin; propose that calpain 1 interacts in a resting state with cytoskeletal targets PMID: 14622253
21. The utility of 2 variants of CAPN1 as markers for meat tenderness in U.S. bddf cattle is reported. PMID: 15537766
22. Data show that calpain I is located at the periphery of the Z-band and at the midpoint of the I-band in skeletal muscle myofibrils. PMID: 15885106
23. Data show that gamma-filamin formed a stable complex in vitro and in cells with calpain 1 in the absence of calcium stimulation. PMID: 16297652
24. The mu-calpain-mediated proteolytic modification of TnT by removing the NH2-terminal variable region of TnT may act as an acute mechanism to adjust muscle contractility under stress conditions. PMID: 16981728
25. direct measurement of epistatic interactions of causative mutations for quantitative trait loci (QTL) at calpain 1 (CAPN1), located on chromosome 29, with causative mutations for QTL variation at calpastatin (CAST), located on chromosome 7 PMID: 17603104
26. Molecular association between mu-calpain and calpastatin in the mitochondria indicating that calpastatin could play an important role in preventing uncontrolled activity of mu-calpain. PMID: 17868638
27. polymorphisms in CAPN1 might be one of the important genetic factors involved in carcass quality in beef cattle PMID: 18423040
28. the protective effect exerted by HSP90 on eNOS degradation mediated by calpain represents a novel and critical mechanism that assures the reversibility of the intracellular trafficking and activation of the synthase PMID: 18682401
29. A fragment (exon 8 to 10) of the CAPN1 gene was sequenced and genotyped in a sample of the main Spanish maternal beef breeds including Retinta, Morucha, and Avilena Negra-Iberica. PMID: 19544213

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KEGG: bta:281661

STRING: 9913.ENSBTAP00000011678

UniGene: Bt.252